[Change in lipid peroxidation in patients with primary osteoarthrosis deformans]

The content of blood lipid peroxidation products was studied in 62 patients with primary degenerative osteoarthrosis. High concentrations of malonic dialdehyde and acylhydroperoxide were revealed in multiple involvement of the joints, in the presence of reactive synovitis, and at the initial stage of disease. Enhanced lipid peroxidation reflected antioxidant deficiency. Antioxidants were recommended for the correction of disturbed lipid peroxidation in degenerative osteoarthrosis. Vitamin E (antioxidant of direct action) at a dose of 100 mg/day as part of multimodality therapy caused a decrease in the blood level of primary and secondary products of lipid peroxidation. Vitamin E was indicated in multiple involvement of the joints and reactive synovitis at the initial stage of degenerative osteoarthrosis.