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Factors influencing left ventricular ejection fraction in patients with coronary microvascular disease and

Henry Anselmo Mayala1, Magesa Mafuru2, Abdalah Mkangala3

  • 1Jakaya Kikwete Cardiac Institute, P. O. Box 65141, West Upanga, Kalenga Street, Ilala District, Dar es Salaam, Tanzania. henrymayala@yahoo.co.uk.

BMC Research Notes
|March 18, 2020
PubMed

Insights

In patients with coronary microvascular disease, left ventricular ejection fraction is negatively impacted by low-density lipoprotein and B-type natriuretic peptide. Coronary flow reserve positively correlates with left ventricular ejection fraction.

Area of Science:

  • Cardiology
  • Internal Medicine
  • Biochemistry

Background:

  • Coronary microvascular disease (CMD) and obstructive coronary artery disease (CAD) significantly impact cardiac function.
  • Left ventricular ejection fraction (LVEF) is a key indicator of heart health, but its determinants in CMD are complex.

Purpose of the Study:

  • To investigate the relationships between LVEF and biomarkers like low-density lipoprotein (LDL), B-type natriuretic peptide (BNP), Troponin I, and coronary flow reserve (CFR).
  • To identify predictors of LVEF in patients with CMD, both with and without obstructive CAD.

Main Methods:

  • Retrospective analysis of patient data including LVEF, LDL, BNP, Troponin I, and CFR.
  • Statistical evaluation to determine correlations and predictive factors for LVEF.

Main Results:

  • In patients with both obstructive CAD and CMD, LVEF showed inverse relationships with LDL, BNP, and Troponin I, but a direct relationship with CFR.
  • In patients with obstructive CAD only, LVEF was negatively associated with LDL and BNP.
  • Predictors of LVEF in CMD patients included age, blood pressure, lipids, red cell distribution width, HbA1c, symptoms, NYHA class, alcohol use, hypertension, diabetes, Troponin I, and BNP levels.

Conclusions:

  • Biomarkers like LDL, BNP, and Troponin I are associated with reduced LVEF in CMD patients.
  • CFR is a positive correlate of LVEF in patients with combined CMD and obstructive CAD.
  • A multifactorial approach is needed to predict and manage LVEF in patients with CMD.
Abstract

Keywords:
B-type natriuretic peptide (BNP)Coronary artery microvascular dysfunction (CMVD)Coronary flow reserve (CFR)Left ventricular ejection fraction (LVEF)Low density lipoprotein- cholesterol (LDL-c)

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