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Utility of Dissociated Intrinsic Hand Muscle Atrophy in the Diagnosis of Amyotrophic Lateral Sclerosis
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The anterior limb of the internal capsule: Anatomy, function, and dysfunction
Karim Mithani1, Benjamin Davison1, Ying Meng1
1Sunnybrook Research Institute, Toronto, Ontario, Canada.
Behavioural Brain Research
|March 18, 2020
Summary
Neurosurgery for severe psychiatric diseases is re-emerging, with the anterior limb of the internal capsule (ALIC) showing promise as a surgical target. Further research using advanced neuroimaging will refine ALIC
Area of Science:
- Neurosurgery
- Psychiatry
- Neuroscience
Background:
- Neurosurgery for refractory psychiatric conditions has resurged due to improved techniques.
- Optimal surgical targets remain debated, often based on historical data.
- The anterior limb of the internal capsule (ALIC) is a key area of interest.
Purpose of the Study:
- To review the literature on the anterior limb of the internal capsule (ALIC).
- To explore the ALIC's role in psychiatric disease pathophysiology and treatment.
- To evaluate the ALIC as a surgical target for refractory mental illnesses.
Main Methods:
- Comprehensive literature review.
- Analysis of functional anatomy of the ALIC.
- Discussion of ALIC's involvement in psychiatric disorders.
Main Results:
- The ALIC is structurally integrated into the limbic system.
- It plays a role in cognitive and emotional processes relevant to mental illness.
- Evidence supports the ALIC as a viable target for neurosurgical intervention.
Conclusions:
- The anterior limb of the internal capsule (ALIC) is a well-supported target for neurosurgery in severe psychiatric diseases.
- Advanced neuroimaging and neuromodulatory techniques will facilitate future research.
- Continued investigation into the ALIC's role in mental illness is warranted.
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