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High Risk of Drug-drug interactions among Hospitalized Patients with kidney Diseases at a Nigerian Teaching Hospital:

Abdulwasiu Adeniyi Busari1, Ibrahim A Oreagba1, Kazeem A Oshikoya2

  • 1Department of Pharmacology, Therapeutics and Toxicology, College of Medicine, University of Lagos, Lagos, Nigeria.

Nigerian Medical Journal : Journal of the Nigeria Medical Association
|March 18, 2020
PubMed
Abstract

Insights

Drug-drug interactions (DDIs) are very common in kidney disease patients in Nigeria, with most interactions being clinically significant and of major severity. Utilizing DDI checkers can help prevent these harmful interactions.

Area of Science:

  • Pharmacology
  • Nephrology
  • Clinical Pharmacy

Background:

  • Drug-drug interactions (DDIs) pose a growing challenge in clinical practice, particularly for patients with chronic conditions like kidney disease.
  • Data on DDIs in chronically ill Nigerian populations are scarce.
  • This study focused on the prevalence and patterns of DDIs in Nigerian patients with kidney diseases.

Purpose of the Study:

  • To investigate the prevalence and patterns of potential drug-drug interactions (DDIs) among kidney disease patients admitted to a tertiary hospital in Lagos, Nigeria.
  • To assess the clinical significance and severity of observed DDIs.
  • To highlight the need for DDI monitoring in this patient population.

Main Methods:

  • A prospective observational study was conducted over three months with 61 adult kidney disease patients.
  • Data on demographics, clinical status, and drug regimens were collected using a standardized pro forma.
  • Potential DDIs were identified and their severity assessed using MICROMEDEX® software.

Main Results:

  • A high prevalence of potential DDIs was observed in 93.7% of prescriptions, with 85.7% being clinically significant drug interactions (CSDIs).
  • Pharmacodynamic DDIs were the most frequent type (91.7%).
  • Most CSDIs were of major severity (24.9%), with 61.4% being moderate.

Conclusions:

  • Exposure to potential DDIs is extremely common in kidney disease patients in Nigeria.
  • The majority of identified CSDIs were of major severity, indicating a significant risk.
  • Implementing DDI checker tools before prescribing is crucial to mitigate clinically significant interactions in patients with kidney diseases.
Keywords:
Chronic kidney diseaseco-administered drugscontraindicationdrug–drug interactionspharmacodynamicspharmacokineticspolypharmacytoxic effect

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