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New Perspectives on Atherogenic Dyslipidaemia and Cardiovascular Disease

Alberto J Lorenzatti1,2, Peter P Toth3,4

  • 1DAMIC Medical Institute, Rusculleda Foundation for Research, Cordoba, Argentina.

European Cardiology
|March 18, 2020
PubMed

Insights

Atherogenic dyslipidemia, marked by high triglycerides and low HDL cholesterol, significantly increases cardiovascular disease risk. Lifestyle changes and medications can manage these lipid abnormalities to reduce residual risk.

Area of Science:

  • Cardiovascular Medicine
  • Metabolic Disorders
  • Lipidology

Background:

  • Atherogenic dyslipidemia is a prevalent lipid abnormality strongly linked to cardiovascular disease (CVD) risk.
  • Despite statin and non-statin therapies, residual CVD risk persists due to non-LDL cholesterol patterns.
  • These patterns include elevated triglycerides, low HDL cholesterol, small dense LDL particles, and postprandial hyperlipidaemia.

Purpose of the Study:

  • To review the pathophysiology of atherogenic dyslipidemia.
  • To explore its association with atherosclerotic cardiovascular disease development.
  • To outline therapeutic strategies for managing these lipid alterations and preventing CVD events.

Main Methods:

  • Literature review of pathophysiology.
  • Analysis of the relationship between lipid profiles and atherosclerosis.
  • Summary of current lifestyle and pharmacological interventions.

Main Results:

  • Atherogenic dyslipidemia is associated with insulin resistance, type 2 diabetes, and obesity.
  • These lipid modifications contribute to increased atherosclerotic cardiovascular disease risk.
  • Therapeutic approaches involve lifestyle modifications and pharmacological treatments.

Conclusions:

  • Atherogenic dyslipidemia represents a significant challenge in cardiovascular disease prevention.
  • Understanding its pathophysiology is crucial for effective management.
  • A combination of lifestyle changes and targeted therapies is necessary to mitigate residual cardiovascular risk.

Keywords:
Apolipoprotein Batherogenic dyslipidaemiaatherosclerosisezetimibefibratelipoproteinomega-3 fatty acidproprotein convertase subtilisin/kexin type 9statintriglycerides

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