Related Experiment Video
Updated: Dec 26, 2025
Tumorsphere Derivation and Treatment from Primary Tumor Cells Isolated from Mouse Rhabdomyosarcomas
Published on: September 13, 2019
[Orbital rhabdomyosarcoma in a 9-month-old baby]
Soumya Benziane1, Rajae Daoudi1
1Hôpital des Spécialités, Rabat, Maroc.
Insights
A rare embryonic rhabdomyosarcoma in a 9-month-old infant presented as an orbital mass. Despite treatment, the aggressive tumor rapidly progressed, leading to the infant's death.
Area of Science:
- Pediatric Oncology
- Ophthalmology
- Pathology
Abstract:
A 9-month-old baby, born within the normal period of gestation and with normal psychomotor development, presented with a rapidly progressive small swelling persisting for several months and evolving towards an inflammatory status. CT scan of the orbit and brain after contrast injection showed right intraorbital tissue mass forcing the eyeball upwards and outwards. The patient underwent surgical biopsy of the lesion. The diagnosis was necrosed sarcomatous tumoral proliferation with undifferentiated cells of small size; immuno-histochemical examination revealed embryonic rhabdomyosarcome. The patient was lost to follow-up for 3 months, then re-consulted. MRI evaluation was requested. This showed a significant increase in tumor volume. Initial chemotherapy was recommended followed by locoregional radiotherapy. The baby died a few months later.
Related Concept Videos
01:20The Retinoblastoma Gene
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
01:03Rous Sarcoma Virus (RSV) and Cancer
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...