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Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model
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Chronic urticaria and thyroid pathology.

Sandra Nora Gonzalez-Diaz1, Mario Sanchez-Borges2, Diana Maria Rangel-Gonzalez1

  • 1Centro Regional de Alergia e Inmunología Clinica, Hospital Universitario "Dr. José Eleuterio González", Ave. Gonzalitos y Madero, s/n, Colonia Mitras Centro, CP. 64460, Monterrey, Nuevo Leon, Mexico.

The World Allergy Organization Journal
|March 18, 2020
PubMed
Summary
This summary is machine-generated.

Chronic spontaneous urticaria (CSU) is a skin condition often linked to autoimmune diseases, particularly autoimmune thyroid disease (ATD). Understanding this connection may reveal new treatment pathways for CSU.

Keywords:
AAbs, autoantibodiesAD, autoimmune diseasesAE, angioedemaAMA, antithyroid microsomal antibodyASST, autologous serum skin testATAbs, anti-thyroid autoantibodiesATD, autoimmune thyroid diseaseAutoimmunityBAT, basophil activation testCAU, chronic autoimmune urticariaCSU, chronic spontaneous urticariaCU, chronic urticariaChronic urticariaDAMPs, damage-associated molecular patternsFcεRIa, high affinity IgE receptorGD, Graves' diseaseHT, Hashimoto's thyroiditis/autoimmune thyroiditisHistamineICU, inducible chronic urticariaIFN-γ, gamma interferonIL, InterleukinIgE, Immunoglobulin EIgG, Immunoglobulin GLevothyroxineNSAH, non-sedating antihistaminesPAF, platelet activating factorPAMPs, pathogen-associated molecular patternsT4L, free thyroxineTG, thyroglobulinTGAbs, anti-thyroglobulin antibodiesTLR, Toll-like receptorsTNF-α, tumor necrosis factor alphaTPOAbs, anti-thyroid peroxidase antibodiesTSH, thyroid stimulating hormoneTSHR, thyroid stimulating hormone receptorThyroid diseaseTreg, regulatory T cellsUAS, urticaria activity scoreUrticariaVEGF, vascular endothelial growth factor

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Area of Science:

  • Immunology
  • Dermatology
  • Endocrinology

Background:

  • Urticaria, characterized by itchy wheals and swelling, is classified by duration and triggers.
  • Chronic spontaneous urticaria (CSU) persists over 6 weeks without identifiable triggers.
  • CSU is frequently associated with autoimmunity, including autoimmune thyroid disease (ATD).

Purpose of the Study:

  • To review the pathophysiology of chronic spontaneous urticaria.
  • To explore the association between CSU and autoimmune thyroid disease.
  • To discuss potential therapeutic implications of the CSU-ATD link.

Main Methods:

  • Literature review of existing studies on CSU and ATD.
  • Analysis of immunological mechanisms shared between CSU and autoimmune conditions.
  • Examination of evidence linking ATD therapies to CSU remission.

Main Results:

  • CSU affects 4.3%-57.4% of patients with ATD.
  • Autoimmunity is implicated in 30-45% of CSU cases.
  • Therapeutic strategies for ATD may influence CSU, though more research is needed.

Conclusions:

  • CSU and ATD share common autoimmune pathways.
  • Targeting ATD may offer novel treatment approaches for CSU.
  • Further controlled studies are required to validate therapeutic interventions.