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Analysis of Hematopoietic Stem Progenitor Cell Metabolism
Published on: November 9, 2019
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Energy Metabolism Regulates Stem Cell Pluripotency.
Enkhtuul Tsogtbaatar1, Chelsea Landin1, Katherine Minter-Dykhouse1
1Stem Cell and Regenerative Metabolism Laboratory, Departments of Cardiovascular Diseases and Biochemistry and Molecular Biology, Mayo Clinic, Scottsdale, AZ, United States.
Frontiers in Cell and Developmental Biology
|March 18, 2020
Summary
Pluripotent stem cells (PSCs) exhibit distinct metabolic states, influencing their self-renewal and differentiation. Understanding these metabolic pathways is crucial for comprehending cell fate during development.
Area of Science:
- Cell Biology
- Developmental Biology
- Metabolic Regulation
Background:
- Pluripotent stem cells (PSCs) possess self-renewal and differentiation capabilities.
- Pluripotency exists as a continuum of states with unique metabolic and epigenetic features.
- Naïve and primed PSCs represent distinct states with differing bioenergetic demands.
Purpose of the Study:
- To review the roles of major metabolic pathways in naïve and primed pluripotent stem cell states.
- To explore how metabolism influences the acquisition and maintenance of pluripotency.
- To connect metabolic pathways to cell fate determination during development.
Main Methods:
- Literature review focusing on metabolic pathways in pluripotent stem cells.
- Analysis of metabolic, mitochondrial, and epigenetic features of different PSC states.
- Examination of substrate utilization and energy production in PSCs.
Main Results:
- PSCs require high anabolic precursors and ATP for rapid cell division.
- Metabolic adaptations, including substrate preference and glycolysis, vary with developmental stage.
- Metabolites produced by PSCs can directly impact epigenetic and transcriptional programs.
Conclusions:
- Metabolism is integral to PSC fate, extending beyond anabolism/catabolism to epigenetic governance.
- Understanding metabolic roles in naïve and primed PSCs offers insights into developmental cell fate drivers.
- Metabolic pathways are key regulators in maintaining distinct pluripotent states.
Keywords:
amino acidsglycolysisinduced pluripotent stem cellsnaïve and primed embryonic stem cellsnuclear reprogrammingoxidative metabolismoxidative phosphorylationtricarboxylic acid cycleMore Related Videos
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