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Published on: August 7, 2017
Effect of breastfeeding duration on lung function, respiratory symptoms and allergic diseases in school-age children
Olga Gorlanova1,2, Rhea Appenzeller1,2, Yasmin S Mahmoud1,2
1Pediatric Pulmonology, University Children's Hospital (UKBB), University of Basel, Basel, Switzerland.
Insights
This study found no link between breastfeeding duration and lung function in healthy children. Breastfeeding did not impact respiratory symptoms or allergic conditions by age six.
Area of Science:
- Pediatric Health
- Respiratory Medicine
- Epidemiology
Background:
- Previous studies suggest breastfeeding benefits lung function in children with asthma risk.
- This research investigates breastfeeding's impact in a general healthy population.
Purpose of the Study:
- To assess the association between breastfeeding duration and lung function at age 6.
- To examine the relationship between breastfeeding and respiratory symptoms and allergic conditions in healthy children.
Main Methods:
- Prospective study of 377 healthy infants from birth to 6 years (Bern-Basel Infant Lung Development cohort).
- Breastfeeding duration assessed via weekly phone calls; risk factors collected via questionnaires.
- Lung function measured by spirometry and body plethysmography; fractional exhaled nitric oxide (FeNO) and respiratory symptoms/allergic conditions also assessed.
Main Results:
- Mean breastfeeding duration was 36 weeks.
- No association found between breastfeeding duration and lung function parameters (e.g., FEV1, FRC, TLC, Reff) or FeNO.
- Adjusted analyses revealed no link between breastfeeding duration and respiratory symptoms or allergic conditions.
Conclusions:
- This study found no evidence that breastfeeding duration directly impacts lung function in healthy children.
- Findings do not support a direct effect of breastfeeding on lung function in a low-risk, healthy population.
Background:
A positive effect of breastfeeding on lung function has been demonstrated in cohorts of children with asthma or risk for asthma. We assessed the impact of breastfeeding on lung function and symptoms at the age of 6 years in an unselected, healthy birth cohort.
Methods:
We prospectively studied healthy term infants from the Bern-Basel Infant Lung Development (BILD) cohort from birth up to 6 years. Any breastfeeding was assessed by weekly phone calls during the first year of life. Risk factors (eg, smoking exposure, parental history of allergic conditions, and education) were obtained using standardized questionnaires. The primary outcomes were lung function parameters measured at 6 years of age by spirometry forced expiratory volume in 1 second, body plethysmography (functional residual capacity [FRCpleth ], the total lung capacity [TLCpleth ], and the effective respiratory airway resistance [Reff ]) and fractional exhaled nitric oxide (FeNO). Secondary outcomes included ever wheeze (between birth and 6 years), wheeze in the past 12 months, asthma, presence of allergic conditions, atopic dermatitis, rhinitis, and positive skin prick test at the age of 6 years.
Results:
In 377 children the mean breastfeeding duration was 36 weeks (SD 14.4). We found no association of breastfeeding duration with obstructive or restrictive lung function and FeNO. After adjustment for confounders, we found no associations of breastfeeding duration with respiratory symptoms or the presence of allergic conditions.
Conclusion:
This study found no evidence of an association between breastfeeding and comprehensive lung function in unselected healthy children with long-term breastfeeding. Our findings do not support the hypothesis that the duration of breastfeeding has a direct impact on lung function in a healthy population with low asthmatic risk.
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