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Related Experiment Videos

A new low-frequency antigen BOW (Bowyer).

M A Chaves1, M R Leak, J Poole

  • 1South London Blood Transfusion Centre, London, UK.

Vox Sanguinis
|January 1, 1988
PubMed
Summary

A novel low-frequency red blood cell antigen, BOW, has been identified in English blood donors. This antigen is sensitive to specific enzymes and segregates independently of major blood group systems.

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Area of Science:

  • * Hematology
  • * Immunology
  • * Genetics

Background:

  • * Discovery of novel low-frequency red blood cell antigens is crucial for transfusion medicine.
  • * Existing polyspecific reagents may contain antibodies to such antigens, impacting compatibility testing.

Purpose of the Study:

  • * To report the identification and initial characterization of a new red blood cell antigen, designated BOW.
  • * To determine the enzymatic sensitivity and genetic segregation of the BOW antigen.

Main Methods:

  • * Detection of the BOW antigen in two unrelated English blood donors.
  • * Testing antigen sensitivity to proteolytic enzymes like alpha-chymotrypsin and pronase.
  • * Family studies to analyze the segregation of the BOW blood group.

Main Results:

  • * The BOW antigen was identified in two unrelated English blood donors.
  • * The BOW antigen demonstrated sensitivity to alpha-chymotrypsin and pronase.
  • * Genetic analysis confirmed that the BOW blood group segregates independently from ABO, Rh, MNSs, P1, and Kell systems.

Conclusions:

  • * BOW represents a newly discovered low-frequency red blood cell antigen.
  • * The BOW antigen's characteristics and independent segregation provide valuable information for blood group genetics.
  • * Further characterization of BOW is warranted for its clinical significance in transfusion practices.

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