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A new low-frequency antigen BOW (Bowyer).

M A Chaves1, M R Leak, J Poole

  • 1South London Blood Transfusion Centre, London, UK.

Vox Sanguinis
|January 1, 1988
PubMed
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A novel low-frequency red blood cell antigen, BOW, has been identified in English blood donors. This antigen is sensitive to specific enzymes and segregates independently of major blood group systems.

Area of Science:

  • * Hematology
  • * Immunology
  • * Genetics

Background:

  • * Discovery of novel low-frequency red blood cell antigens is crucial for transfusion medicine.
  • * Existing polyspecific reagents may contain antibodies to such antigens, impacting compatibility testing.

Purpose of the Study:

  • * To report the identification and initial characterization of a new red blood cell antigen, designated BOW.
  • * To determine the enzymatic sensitivity and genetic segregation of the BOW antigen.

Main Methods:

  • * Detection of the BOW antigen in two unrelated English blood donors.
  • * Testing antigen sensitivity to proteolytic enzymes like alpha-chymotrypsin and pronase.
  • * Family studies to analyze the segregation of the BOW blood group.

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Main Results:

  • * The BOW antigen was identified in two unrelated English blood donors.
  • * The BOW antigen demonstrated sensitivity to alpha-chymotrypsin and pronase.
  • * Genetic analysis confirmed that the BOW blood group segregates independently from ABO, Rh, MNSs, P1, and Kell systems.

Conclusions:

  • * BOW represents a newly discovered low-frequency red blood cell antigen.
  • * The BOW antigen's characteristics and independent segregation provide valuable information for blood group genetics.
  • * Further characterization of BOW is warranted for its clinical significance in transfusion practices.