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Preparation and Maintenance of Bioexclusion IsoPositive Cage Experiment for Human Fecal Transplantation into Germ-Free Mice

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Gut microbiome transfer-Finding the perfect fit.

Karen S W Leong^1,2, Justin M O'Sullivan^1,2, José G B Derraik^1,2,3,4

¹Liggins Institute, University of Auckland, Auckland, New Zealand.

Clinical Endocrinology

|March 18, 2020

Summary

This summary is machine-generated.

Gut microbiome transfer (GMT), or fecal microbiota transplantation (FMT), shows promise for obesity and metabolic diseases. This review explores factors influencing GMT success and its potential applications in these conditions.

Keywords:

C difficile donor faeces infusion faecal microbiota transplantation gut microbiome intestinal microbiota metabolic syndrome obesity

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Area of Science:

Microbiology
Gastroenterology
Metabolic Science

Background:

Gut microbiome transfer (GMT), also known as fecal microbiota transplantation (FMT), is established for recurrent C. difficile infection.
Emerging research investigates GMT for chronic conditions like inflammatory bowel disease, obesity, and metabolic diseases, with mixed clinical trial results.
Limited data exist for GMT in obesity and metabolic diseases, necessitating further investigation into influencing factors.

Purpose of the Study:

To explore human, microbial, and formulation factors impacting GMT success.
To review current literature on GMT's efficacy and safety for obesity, type 2 diabetes, and metabolic diseases.
To highlight recent advances and potential adverse effects of GMT in metabolic health.

Main Methods:

Literature review of published studies on GMT for obesity and metabolic diseases.
Analysis of factors including stool processing, delivery methods, and pretreatment protocols.
Examination of precision bacteriotherapy and GMT frequency.

Main Results:

Clinical trial results for GMT in chronic conditions are mixed.
Few studies with small participant numbers and short follow-up durations exist for obesity and metabolic diseases.
GMT research in metabolic diseases is advancing, with ongoing evaluation of efficacy and safety.

Conclusions:

GMT holds potential for treating obesity and metabolic diseases, but requires further research.
Optimizing GMT preparation, administration, and formulation is crucial for therapeutic success.
Careful consideration of potential adverse effects is necessary for safe GMT application in metabolic disorders.