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Updated: Dec 26, 2025

Solid-phase Synthesis of [4.4] Spirocyclic Oximes
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Oxidative Carbon Backbone Rearrangement in Rishirilide Biosynthesis.

Olga Tsypik1, Roman Makitrynskyy1, Britta Frensch2

  • 1Department of Pharmaceutical Biology and Biotechnology, Institute of Pharmaceutical Sciences, Albert-Ludwigs-Universität Freiburg, Stefan-Meier-Straße 19, 79104 Freiburg, Germany.

Journal of the American Chemical Society
|March 18, 2020
PubMed
Summary

This study reveals how Streptomyces bottropensis enzymes RslO5, RslO9, and RslO8 rearrange polyketide precursors. These redox tailoring steps generate complex molecules like rishirilides and lupinacidin A.

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