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Design of potent Mincle signalling agonists based on an alkyl β-glucoside template
Dylan G M Smith1, Yuki Hosono, Masahiro Nagata
1School of Chemistry and Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, Vic, 3010, Australia. sjwill@unimelb.edu.au.
Abstract:
The innate immune receptor Mincle senses lipid-based molecules derived from pathogens, commensals and altered self. Based on emerging structure-activity relationships we design simple alkyl 6-O-acyl-β-d-glucosides that are effective agonists of Mincle and signal with potency on par with the prototypical ligand trehalose dimycolate.
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