Complement: Bridging the innate and adaptive immune systems in sterile inflammation

Area of Science:

• Immunology
• Inflammation Biology

Background:

• The complement system is a crucial amplifier of innate and adaptive immunity.
• Its role in sterile inflammation, linked to chronic diseases, is increasingly recognized.

Purpose of the Study:

• To review the complement system's role in sterile inflammation.
• To highlight its function in bridging innate and adaptive immunity.
• To identify complement as an anti-inflammatory drug target.

Main Methods:

• Literature review of complement system activators, effectors, and targets in sterile inflammation.
• Analysis of examples including hypertension, cancer, transplant rejection, and neuroinflammation.

Main Results:

• Complement activation by damaged tissues contributes to chronic inflammation.
• The complement system bridges innate and adaptive immunity in sterile inflammatory conditions.
• Specific diseases demonstrate complement's role in immune system integration.

Conclusions:

• The complement system is a significant factor in sterile inflammation and noncommunicable diseases.
• Its role in bridging immune responses makes it a viable anti-inflammatory drug target.