Vascular, flow and perfusion abnormalities in Parkinson's disease
Chunyan Zhang1, Bo Wu2, Xiao Wang1
1Department of MRI, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.
Parkinsonism & Related Disorders
|March 18, 2020
Summary
Vascular abnormalities, including reduced brain blood flow and jugular vein issues, were more common in Parkinson's disease (PD) patients. These findings suggest potential early biomarkers for PD diagnosis and research.
Area of Science:
- Neurology
- Medical Imaging
- Vascular Biology
Background:
- Reduced cerebral blood flow or impaired jugular venous outflow may indicate Parkinson's disease (PD).
- Midbrain iron accumulation is a known hallmark of PD.
Purpose of the Study:
- To compare vascular abnormalities, blood flow, and midbrain iron content in PD patients versus healthy controls (HCs).
Main Methods:
- 85 PD patients and 85 HCs underwent 3T MRI.
- Assessed venous structures (MR venography), cerebral blood flow (2D flow quantification), and substantia nigra iron (susceptibility mapping).
Main Results:
- 52% of PD patients had severe venous abnormalities, vs. 14% of HCs.
- PD patients showed significantly lower total arterial flow (tA) (10.9 vs. 11.6 ml/s).
- PD patients exhibited higher heart rates, lower perfusion, and increased midbrain iron.
Conclusions:
- PD patients displayed abnormal venous structures, reduced flow, and lower perfusion compared to HCs.
- These vascular indicators may serve as early biomarkers for Parkinson's disease.
- Findings open new research avenues into PD etiology.
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