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[Drugs--between empirical and rational use].

P Oehme1

  • 1Institut für Wirkstofforschung, Akademie der Wissenschaften der DDR, Berlin.

Zeitschrift Fur Die Gesamte Innere Medizin Und Ihre Grenzgebiete
|November 15, 1988
PubMed
Summary

This paper reviews drug development from animal experiments to computer-aided design, emphasizing clinical therapy and the placebo effect. Integrating drug therapies with unspecific patient care is crucial for effective medical treatment.

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Area of Science:

  • Pharmacology and Therapeutics
  • Medical Research Methodology
  • Clinical Psychology

Context:

  • The evolution of drug discovery from early animal studies to sophisticated computational methods.
  • The increasing complexity of therapeutic strategies and the need for integrated approaches.
  • The underappreciated role and scientific investigation of the placebo phenomenon in patient outcomes.

Purpose:

  • To provide a comprehensive overview of drug research's historical development and future directions.
  • To highlight the significance of clinical therapy research and its prospective importance.
  • To re-evaluate the placebo effect, exploring new research avenues and its medical implications.

Summary:

  • Traces the trajectory of experimental drug research from foundational animal models to advanced rational computerized drug design.
  • Discusses the current and future relevance of clinical therapy research, emphasizing a holistic view of treatment.
  • Examines the placebo phenomenon in detail, advocating for its integration into medical understanding and practice.

Impact:

  • Informs the integration of specific therapeutic agents (drugs) with non-specific therapeutic elements in patient care.
  • Underscores the necessity of a combined approach, considering both pharmacological and psychological aspects of treatment.
  • Suggests future research directions for optimizing therapeutic outcomes by understanding the interplay between drug action and patient response.

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