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Related Concept Videos

Epigenetic Regulation01:37

Epigenetic Regulation

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Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
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Epigenetic Regulation01:46

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Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
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Targeted Cancer Therapies02:57

Targeted Cancer Therapies

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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
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Genomic Imprinting and Inheritance02:30

Genomic Imprinting and Inheritance

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Diploid organisms inherit genetic material through chromosomes from both parents. Copies of the same gene are known as alleles. In most cases, both alleles are simultaneously expressed and allow various cellular processes to function optimally. If one of the alleles is missing or mutated, the expression of the other allele can compensate; however, this is not true for all genes.
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...
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Related Experiment Video

Updated: Dec 26, 2025

An Integrated Platform for Genome-wide Mapping of Chromatin States Using High-throughput ChIP-sequencing in Tumor Tissues
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Targeting Epigenetic Dependencies in Solid Tumors: Evolutionary Landscape Beyond Germ Layers Origin.

Francesca Citron1, Linda Fabris2

  • 1Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77054, USA.

Cancers
|March 19, 2020
PubMed
Summary

Cancer epigenetics drives tumor progression and drug resistance. Targeting chromatin remodeling offers new avenues for personalized cancer therapies, improving patient outcomes in rare, aggressive cancers.

Keywords:
cancer stem cellepigeneticsglioblastomaovarian cancerpancreatic cancertargeted therapy

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Area of Science:

  • Oncology
  • Molecular Biology
  • Epigenetics

Background:

  • Cancer biology complexity necessitates understanding rare tumor mechanisms.
  • Epigenetic alterations are key drivers in tumorigenesis and progression.
  • Drug resistance in cancers like ovarian cancer, pancreatic cancer, and glioblastoma is a major challenge.

Purpose of the Study:

  • To review the role of epigenetics in cancer development and progression.
  • To highlight the impact of chromatin remodeling on tumor architecture and fitness.
  • To explore advances in epigenome targeting for personalized cancer therapy.

Main Methods:

  • Review of recent literature on cancer epigenetics.
  • Analysis of genomic alterations in epigenetic modulators.
  • Discussion of chromatin remodeling's role in tumor microenvironment.

Main Results:

  • Epigenome dependency is crucial for cancer cell processes.
  • Chromatin remodeling influences tumor architecture and fitness.
  • Epigenetic targeting strategies are emerging for therapeutic use.

Conclusions:

  • Epigenetic mechanisms are vital in rare, aggressive cancers.
  • Targeting the epigenome holds promise for individualized cancer treatment.
  • Translating epigenome knowledge into clinical practice can improve patient outcomes.