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Related Concept Videos

Cancer Stem Cells and Tumor Maintenance02:40

Cancer Stem Cells and Tumor Maintenance

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Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
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Distinctive Features of Adult Stem Cells vs Cancer Stem Cells01:18

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A stem cell is an unspecialized cell that can divide without limit as needed and can, under specific conditions, differentiate into specialized cells.
Adult stem cells
Adult stem cells are tissue-specific; hence, they divide to develop the tissue from which they originate. One type of adult stem cell is the epithelial stem cell, which gives rise to the keratinocytes in the multiple layers of epithelial cells in the epidermis of the skin. Adult bone marrow has three distinct types of stem cells:...
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Multipotency of Hematopoietic Stem Cells01:19

Multipotency of Hematopoietic Stem Cells

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The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...
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Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

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Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
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Liver Regeneration01:24

Liver Regeneration

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The liver is an important organ in vertebrates that plays an essential role in metabolism. It is also responsible for storing and redistributing nutrients such as carbohydrates, fats, and vitamins in the body. Additionally, the liver releases bile salts which are critical for digesting food and eliminating toxic metabolites from the body.
Cells of Liver
The liver comprises four major types of cells— hepatocytes, stellate, Kupffer, and sinusoidal endothelial cells. The hepatocytes are...
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Regulation of Hematopoietic Stem Cells01:01

Regulation of Hematopoietic Stem Cells

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All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
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Isolation of CD133+ Liver Stem Cells for Clonal Expansion
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The Cancer Stem Cell in Hepatocellular Carcinoma.

Lucas-Alexander Schulte1, Juan Carlos López-Gil2,3, Bruno Sainz2,3,4

  • 1Department of Internal Medicine I, Ulm University, 89081 Ulm, Germany.

Cancers
|March 19, 2020
PubMed
Summary

Cancer stem cells (CSCs) drive tumor growth, metastasis, and chemoresistance. Targeting these cells offers a promising therapeutic strategy for cancer recurrence, particularly in hepatocellular carcinoma.

Keywords:
cancer stem cellshepatocellular carcinomaliver cancer

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Exploring the Potential of Mesenchymal Stem Cell Sheet on The Development of Hepatocellular Carcinoma In Vivo
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Area of Science:

  • Oncology
  • Cancer Biology
  • Cellular Biology

Background:

  • Intra-tumoral cellular heterogeneity is recognized, leading to the cancer stem cell (CSC) concept.
  • CSCs possess self-renewal and differentiation capabilities, forming a tumor hierarchy.
  • CSCs are implicated in tumor initiation, metastasis, and chemotherapy resistance.

Purpose of the Study:

  • To review the cancer stem cell (CSC) concept in cancer.
  • To focus on the role of CSCs in hepatocellular carcinoma.

Main Methods:

  • Literature review of CSC biology.
  • Focus on CSCs in hepatocellular carcinoma.

Main Results:

  • CSCs are solely responsible for tumor recurrence.
  • CSCs are a potential therapeutic target.

Conclusions:

  • Understanding CSC biology is crucial for developing new clinical therapeutic approaches.
  • Targeting CSCs may overcome tumor recurrence and chemoresistance in cancers like hepatocellular carcinoma.