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Therapeutic Nanoemulsion: Concept to Delivery
Md A Barkat1, Harshita1, Md Rizwanullah2
1Department of Pharmaceutics, College of Pharmacy, University of Hafr Al Batin, Al Jamiah, Hafr Al Batin 39524, Saudi Arabia.
Current Pharmaceutical Design
|March 19, 2020
Summary
Nanoemulsions (NEs) are stable, nanoscale oil-in-water systems offering enhanced bioavailability for drug delivery. This article explores their development, applications, and industrial scalability.
Area of Science:
- Pharmaceutical Sciences
- Materials Science
Background:
- Nanoemulsions (NEs) are kinetically stable, heterogeneous systems of oil and water, stabilized by surfactants, with droplet sizes up to 100 nm.
- NEs exhibit improved stability, optical clarity, and enhanced bioavailability due to their nanoscale particle size.
- Conventional emulsion principles only partly apply to NEs, necessitating specialized design and optimization strategies.
Purpose of the Study:
- To provide a comprehensive overview of nanoemulsion (NE) technology for drug delivery.
- To discuss the journey of NEs from concept to practical application.
- To address the industrial scalability and clinical relevance of NEs.
Main Methods:
- Review of existing literature on nanoemulsion formulation and characterization.
- Analysis of factors influencing NE stability and performance.
- Discussion of case studies and commercial examples of NE applications.
Main Results:
- NEs offer significant advantages for drug delivery, including improved absorption and targeted delivery.
- Challenges remain in the precise design, development, and optimization of NEs.
- Successful industrial scale-up and clinical translation of NEs are feasible.
Conclusions:
- Nanoemulsions represent a promising drug delivery platform with unique physicochemical properties.
- Further research is needed to fully understand and optimize NE formulation and application.
- The industrial scalability and clinical utility of NEs are increasingly recognized.
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