Related Experiment Video
Updated: Dec 26, 2025

Synthesis of a Borylated Ibuprofen Derivative Through Suzuki Cross-Coupling and Alkene Boracarboxylation Reactions
Published on: November 30, 2022
A case of rectal ulcers during aspirin therapy in acute Kawasaki disease
Yong Han1, Chenmin Hu1, Yanping Yu2
1Department of Pediatrics, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Insights
Kawasaki disease (KD) can rarely cause lower gastrointestinal bleeding. This case highlights rectal ulcers as a cause in a child treated with aspirin.
Area of Science:
- Pediatrics
- Cardiology
- Gastroenterology
Background:
- Kawasaki disease (KD) is a leading cause of acquired heart disease in children.
- Gastrointestinal symptoms are common, but lower GI bleeding is rare.
Observation:
- A 3-year-old boy presented with typical Kawasaki disease symptoms.
- He developed lower gastrointestinal bleeding on the third day of aspirin therapy.
Findings:
- The bleeding was attributed to rectal ulcers.
- This represents a rare complication of Kawasaki disease treatment.
Implications:
- Clinicians should consider lower GI bleeding in KD patients, even during treatment.
- Rectal ulcers may be an underrecognized cause of GI bleeding in KD.
Abstract:
Kawasaki disease (KD) is an acute febrile multisystem vasculitis and has been recognized to be one of the most common causes of acquired heart disease in children. Although gastrointestinal symptoms including vomiting, diarrhea, and abdominal pain are not uncommon in KD patients, KD with lower gastrointestinal bleeding is quite rare. Here, we describe a 3-year-old boy with typical KD who had lower gastrointestinal bleeding caused by rectal ulcers on the third day of aspirin therapy.
Related Concept Videos
Peptic Ulcer Disease IV: Management
The therapeutic approach involves ensuring adequate rest, implementing drug therapy, promoting smoking cessation, making dietary modifications, and emphasizing long-term follow-up care.
Pharmacological management
The prevailing therapy for peptic ulcers involves a combination of managing the patient's current...
Drugs for Peptic Ulcer Disease: Prostaglandin Analogs as Mucosal Protective Agents
Non-steroidal anti-inflammatory drugs (NSAIDs) can induce peptic ulcers by inhibiting cyclooxygenase, decreasing...
Drugs for Peptic Ulcer Disease: Sucralfate as Mucosal Protective Agents
In this scenario, mucosal protective agents like sucralfate play an essential role. Sucralfate, a complex of sulfated sucrose and aluminum hydroxide, demonstrates its usefulness in acidic conditions,...
Drugs for Treatment of Ulcerative Colitis in IBD
Acid Suppressive Drugs for Peptic Ulcer Disease: Proton Pump Inhibitors
Gastric acid, a potent cocktail of hydrogen and chloride ions, is produced in specialized parietal cells within the...
Peptic Ulcer Disease II: Pathophysiology
Damaging agents such as Helicobacter pylori, gastric acid, pepsin, and nonsteroidal anti-inflammatory drugs (NSAIDs) can weaken the mucosal defense, allowing hydrogen ions to infiltrate back and harm epithelial cells.

