Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Revisiting Critical Thinking and Clinical Judgment in Nursing Education.

The Journal of nursing education·2026
Same author

A brain-specific microRNA, <i>miR-1000</i>, regulates lipid homeostasis via neuropeptide-like precursor 1 in <i>Drosophila melanogaster</i>.

Genes & development·2026
Same author

Mammalian-conserved <i>Drosophila</i> miR-6 regulation of LRP1 in the heart protects against normal cardiac aging.

American journal of physiology. Heart and circulatory physiology·2025
Same author

Regulation of miR-219 and its target RalGPS dictates acute synaptic plasticity at the <i>Drosophila</i> neuromuscular junction.

bioRxiv : the preprint server for biology·2025
Same author

Diet, nutrition, and healthy aging: Are miRNAs the link? A narrative review.

The journal of nutrition, health & aging·2025
Same author

Torso synthetic CT generation by integrating deep learning and segmentation for FDG-PET/MR attenuation correction.

Biomedical physics & engineering express·2025

Related Experiment Video

Updated: Dec 26, 2025

Dissection and Imaging of Active Zones in the Drosophila Neuromuscular Junction
06:05

Dissection and Imaging of Active Zones in the Drosophila Neuromuscular Junction

Published on: April 27, 2011

15.9K

Drosophila enabled promotes synapse morphogenesis and regulates active zone form and function.

Elizabeth M McNeill1, Cheryl Thompson2, Brett Berke3

  • 1Department of Food Science and Human Nutrition, Iowa State University, Ames, IA, USA. emcneill@iastate.edu.

Neural Development
|March 19, 2020
PubMed
Summary
This summary is machine-generated.

Enabled (Ena) protein is crucial for presynaptic terminal development and function, regulating bouton formation and neurotransmission. This study reveals Ena

Keywords:
ActinDrosophilaEna/VASP, DlarReceptor protein tyrosine phosphataseSynapse

More Related Videos

Analyzing Synaptic Modulation of Drosophila melanogaster Photoreceptors after Exposure to Prolonged Light
11:36

Analyzing Synaptic Modulation of Drosophila melanogaster Photoreceptors after Exposure to Prolonged Light

Published on: February 10, 2017

6.8K
Channelrhodopsin2 Mediated Stimulation of Synaptic Potentials at Drosophila Neuromuscular Junctions
09:12

Channelrhodopsin2 Mediated Stimulation of Synaptic Potentials at Drosophila Neuromuscular Junctions

Published on: March 16, 2009

14.0K

Related Experiment Videos

Last Updated: Dec 26, 2025

Dissection and Imaging of Active Zones in the Drosophila Neuromuscular Junction
06:05

Dissection and Imaging of Active Zones in the Drosophila Neuromuscular Junction

Published on: April 27, 2011

15.9K
Analyzing Synaptic Modulation of Drosophila melanogaster Photoreceptors after Exposure to Prolonged Light
11:36

Analyzing Synaptic Modulation of Drosophila melanogaster Photoreceptors after Exposure to Prolonged Light

Published on: February 10, 2017

6.8K
Channelrhodopsin2 Mediated Stimulation of Synaptic Potentials at Drosophila Neuromuscular Junctions
09:12

Channelrhodopsin2 Mediated Stimulation of Synaptic Potentials at Drosophila Neuromuscular Junctions

Published on: March 16, 2009

14.0K

Area of Science:

  • Neuroscience
  • Cell Biology
  • Developmental Biology

Background:

  • The actin cytoskeleton is vital for synapse development, neurotransmission, and plasticity.
  • Enabled (Ena), an actin-associated protein, influences Drosophila neuromuscular junction development postsynaptically.
  • Presynaptic roles and regulation of Ena remain largely unknown.

Purpose of the Study:

  • To investigate the presynaptic functions of Ena in neuronal morphology and ultrastructure.
  • To elucidate the regulatory pathway involving Ena at the presynaptic terminal.

Main Methods:

  • Conditional genetic manipulation in Drosophila.
  • Epistasis experiments to determine pathway interactions.

Main Results:

  • Presynaptic Ena promotes bouton and branch morphogenesis, contrasting its postsynaptic inhibitory role.
  • Presynaptic Ena functions downstream of the Dlar receptor tyrosine phosphatase pathway.
  • Ena regulates presynaptic varicosity addition, active zone size, synaptic vesicle recruitment, and spontaneous glutamate release.

Conclusions:

  • Ena is essential for presynaptic terminal morphogenesis and bouton addition, controlled by the Dlar pathway.
  • Ena influences active zone structure and neurotransmission.
  • Ena integrates multiple pathways governing synapse form and function, unlike Dlar.