Tracking the Nonenrolled: Lung Cancer Screening Patterns Among Individuals not Accrued to a Clinical Trial
David E Gerber1, Heidi A Hamann2, Claudia Chavez3
1Department of Population and Data Sciences, University of Texas Southwestern Medical Center, Dallas, TX; Division of Hematology-Oncology, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX; Division of Hematology-Oncology, Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX.
Clinical Lung Cancer
|March 19, 2020
Summary
Lung cancer screening adherence was lower in patients not enrolled in a trial, particularly those unreachable. Demographic factors did not predict trial participation for lung cancer screening.
Area of Science:
- Pulmonology
- Oncology
- Public Health
Background:
- Lung cancer screening data often comes from clinical trials.
- Real-world screening patterns in eligible non-trial participants are less understood.
Purpose of the Study:
- To investigate lung cancer screening patterns in individuals eligible for, but not enrolled in, a screening trial.
- To compare adherence and completion rates between enrolled and non-enrolled patient groups.
Main Methods:
- Prospective trial enrollment for telephone-based navigation during low-dose computed tomography (LDCT) lung cancer screening.
- Comparison of demographic characteristics and LDCT completion rates between enrolled, declined, and unreachable non-enrolled patients.
- Statistical analysis using 2-sample t test and chi-squared test.
Main Results:
- Of 900 individuals approached, 447 were enrolled; 453 were not (251 declined, 202 unreachable).
- No significant demographic differences between enrolled and non-enrolled cohorts.
- LDCT completion rates: 81% enrolled, 73% declined, 49% unreachable (P < .001).
Conclusions:
- Demographic factors did not predict participation in the lung cancer screening trial.
- Lung cancer screening adherence was significantly lower for non-enrolled individuals, especially those unreachable.
- Findings suggest potential improvements for broader lung cancer screening program implementation.
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