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Related Experiment Video

Updated: Dec 26, 2025

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COX-2 in liver fibrosis.

Hu Yang1, Yang Xuefeng2, Wu Shandong3

  • 1Institute of Pathogenic Biology, Hengyang Medical College, University of South China, Hengyang 421001, Hunan, China; Hunan Provincial Key Laboratory for Special Pathogens Prevention and Control, Hengyang 421001, Hunan, China; Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, University of South China, Hengyang 421001, Hunan, China; Department of Gastroenterology, Affiliated Nanhua Hospital, University of South China, Hengyang, Hunan 421002, China.

Clinica Chimica Acta; International Journal of Clinical Chemistry
|March 19, 2020
PubMed
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Cyclooxygenase-2 (COX-2) is crucial in liver fibrosis development by activating hepatic stellate cells and inflammation. This review details COX-2

Keywords:
AutophagyCOX-2Cell senescenceInflammationLiver fibrosis

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Area of Science:

  • Hepatology and Molecular Biology
  • Inflammation and Fibrosis Research

Background:

  • Cyclooxygenase-2 (COX-2) is an inducible enzyme implicated in hepatic fibrogenesis.
  • Hepatic stellate cell (HSC) activation is a key driver of liver fibrosis progression.
  • COX-2 overexpression contributes to inflammation, a major factor in hepatic fibrosis.

Purpose of the Study:

  • To review the regulatory mechanisms and signal transduction pathways of COX-2.
  • To elucidate the multifaceted role of COX-2 in the pathogenesis of liver fibrosis.
  • To consolidate current knowledge on COX-2's involvement in liver diseases like NAFLD and cirrhosis.

Main Methods:

  • Literature review of recent advances in COX-2 research.
  • Analysis of studies on COX-2 regulation and signaling.
  • Examination of COX-2's role in liver fibrosis models and patient data.

Main Results:

  • COX-2 is significantly involved in inflammation, apoptosis, and cellular senescence during liver fibrosis.
  • Altered COX-2 expression is observed in both animal models and human patients with liver fibrosis, including cirrhosis and NAFLD.
  • COX-2 signaling pathways are critical in mediating fibrotic responses in the liver.

Conclusions:

  • COX-2 plays a pivotal and broad role in the development and progression of liver fibrosis.
  • Understanding COX-2 regulation and signaling is essential for developing targeted therapies for liver fibrosis.
  • Further research into COX-2 pathways may offer new therapeutic strategies for liver disease.