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Interleukin-2 druggability is modulated by global conformational transitions controlled by a helical capping switch

Viviane S De Paula1, Kevin M Jude2,3,4, Santrupti Nerli5

  • 1Department of Chemistry and Biochemistry, University of California, Santa Cruz, CA 95064.

Proceedings of the National Academy of Sciences of the United States of America
|March 19, 2020
PubMed
Summary

Interleukin-2 (IL-2) dynamics reveal a conformational switch influencing receptor interactions. Understanding this plasticity is key for designing targeted IL-2 therapies for immune diseases.

Keywords:
IL-2NMRdrug designimmunomodulationprotein dynamics

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