Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Distribution of group-specific component subtypes in multiple sclerosis.

B Lindblom1, G Wetterling, H Link

  • 1State Institute for Blood Group Serology, Linköping University Hospital, Sweden.

Acta Neurologica Scandinavica
|November 1, 1988
PubMed
Summary

This study investigated the group-specific component (Gc) protein subtypes in multiple sclerosis (MS) patients. No significant association was found between Gc protein genetic variations and MS susceptibility.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Ethyl glucuronide (EtG): better than breathalyser or self-reports to detect covert short-term relapses into drinking.

Alcohol and alcoholism (Oxford, Oxfordshire)·2013
Same author

Autosomal SNP typing of forensic samples with the GenPlex™ HID System: results of a collaborative study.

Forensic science international. Genetics·2010
Same author

High frequency of occurrence of CYP2D6 gene duplication/multiduplication indicating ultrarapid metabolism among suicide cases.

Clinical pharmacology and therapeutics·2009
Same author

Incidence of severe reproductive tract complications associated with diagnosed genital chlamydial infection: the Uppsala Women's Cohort Study.

Sexually transmitted infections·2006
Same author

Fatal intoxication cases: cytochrome P450 2D6 and 2C19 genotype distributions.

European journal of clinical pharmacology·2004
Same author

The concentration of nitrite in seminal plasma does not correlate with sperm concentration, sperm motility, leukocytospermia, or sperm culture.

Fertility and sterility·2001

Area of Science:

  • Genetics
  • Immunology
  • Neurology

Background:

  • The group-specific component (Gc) protein is involved in various biological processes and has been implicated in susceptibility to infections.
  • Genetic variations in Gc protein may influence disease risk, including neurological disorders.

Purpose of the Study:

  • To investigate the association between genetic subtypes of Gc protein and susceptibility to multiple sclerosis (MS).

Main Methods:

  • Plasma samples from 88 MS patients were analyzed using isoelectric focusing to determine Gc protein phenotypes.
  • Gc protein allele and phenotype frequencies were compared between MS patients and 3394 control individuals from paternity studies.

Main Results:

  • No statistically significant differences were observed in the frequencies of Gc protein phenotypes or alleles between individuals with MS and the control group.

Related Experiment Videos

  • The study did not find a clear association between specific Gc protein genetic subtypes and the risk of developing MS.

    • Conclusions:

    • The genetic subtypes of Gc protein do not appear to be a significant factor in determining susceptibility to multiple sclerosis.
    • Further research may be needed to explore other potential genetic or environmental factors contributing to MS pathogenesis.