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Related Experiment Videos

Decrease in serum concentration of 5 alpha-pregnane-3,20-dione prior to spontaneous labor.

M Löfgren1, T Bäckström, I Joelsson

  • 1Department of Obstetrics and Gynecology, University of Umeå, Sweden.

Acta Obstetricia Et Gynecologica Scandinavica
|January 1, 1988
PubMed
Summary
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Serum 5 alpha-pregnane-3,20-dione (5 alpha DHP) levels significantly decrease in the final week before spontaneous labor. This hormonal shift in 5 alpha DHP, not progesterone, may precede labor onset.

Area of Science:

  • Reproductive Endocrinology
  • Maternal-Fetal Medicine
  • Steroid Biochemistry

Background:

  • Progesterone is crucial for maintaining pregnancy.
  • Changes in steroid hormone levels are implicated in the initiation of labor.
  • The role of 5 alpha-pregnane-3,20-dione (5 alpha DHP) in spontaneous labor onset requires further elucidation.

Purpose of the Study:

  • To investigate serum concentrations of 5 alpha DHP and progesterone before spontaneous labor.
  • To determine if changes in these hormones precede the onset of labor in uncomplicated pregnancies.

Main Methods:

  • Radioimmunoassay (RIA) methods were used for hormone analysis.
  • Blood samples were collected twice weekly from 36 weeks gestation until labor onset.
  • The study included 13 women with uncomplicated pregnancies and deliveries.

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Main Results:

  • Mean serum 5 alpha DHP concentrations showed a significant decline in the last week of pregnancy.
  • 5 alpha DHP levels decreased from 135 +/- 12 nmol/l five days prior to labor to 111 +/- 10 nmol/l on the day of labor onset (p < 0.005).
  • No significant changes in serum progesterone concentrations were observed during the study period.

Conclusions:

  • A significant decrease in serum 5 alpha DHP precedes spontaneous labor.
  • These findings suggest a potential role for altered 5 alpha DHP production in the initiation of labor.
  • Further research is warranted to understand the precise mechanism of 5 alpha DHP in labor onset.