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Related Experiment Video

Updated: Dec 26, 2025

Author Spotlight: Process Development for the Spray-Drying of Probiotic Bacteria and Evaluation of the Product Quality
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Probiotic Supplements: Hope or Hype?

Yuxuan Wang1, Yinyin Jiang1, Yuxin Deng1

  • 1Department of Biology, College of Science and Technology, Wenzhou-Kean University, Wenzhou, China.

Frontiers in Microbiology
|March 19, 2020
PubMed
Summary

Probiotic supplements, despite health claims, pose risks. Studies show poor survival in gut conditions and potential antibiotic resistance gene transfer, questioning their long-term safety.

Keywords:
Lactobacillusadaptive evolutionantibiotic resistancehealth/dietary supplementshorizontal gene transferlactic acid bacteriaprobiotics

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Area of Science:

  • Microbiology
  • Gastroenterology
  • Public Health

Background:

  • Probiotic bacteria are widely consumed in supplements for purported health benefits.
  • The economic value and consumption of probiotic supplements are rapidly increasing.
  • Potential risks, including antibiotic resistance gene transfer and poor gut survival, are underrepresented.

Purpose of the Study:

  • To evaluate the perceived health benefits versus the long-term safety of probiotic supplements.
  • To investigate probiotic tolerance to gastrointestinal conditions (acid and bile salts).
  • To assess the risk of antibiotic-resistant gene transfer from probiotic supplements.

Main Methods:

  • Assessed tolerance of probiotic supplements to acidic and bile salt conditions.
  • Tested probiotic resistance to multiple antibiotics.
  • Investigated the potential for probiotics to acquire antibiotic resistance *in vitro*.

Main Results:

  • Probiotics from supplements exhibited poor tolerance to acid and bile salts.
  • Tested probiotics displayed resistance to multiple antibiotics.
  • Probiotics demonstrated the ability to gain streptomycin resistance *in vitro*.

Conclusions:

  • Probiotic supplements may not survive unfavorable gut conditions, potentially limiting efficacy.
  • Antibiotic resistance transfer from probiotics is a significant safety concern.
  • Further research and public awareness are needed to balance probiotic supplement hype with safety concerns.