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Related Concept Videos

Mesenchymal Stem Cells01:19

Mesenchymal Stem Cells

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Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their...
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Stem Cell Culture01:17

Stem Cell Culture

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Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
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Multipotency of Hematopoietic Stem Cells01:19

Multipotency of Hematopoietic Stem Cells

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The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...
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Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

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Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
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Embryonic Stem Cells00:57

Embryonic Stem Cells

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Embryonic stem (ES) cells were first discovered in mice in 1981 by Martin Evans. In 1998, James Thomson identified a method to isolate embryonic stem cells from humans. Human embryonic stem cells (hESCs) are obtained from 3-5 day old embryos that remain unused after an in vitro fertilization procedure.
ES cells are grown in a culture medium where they can divide indefinitely, creating ES cell lines. Under certain conditions, ES cells can differentiate, either spontaneously into a variety of...
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Embryonic Stem Cells00:58

Embryonic Stem Cells

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Embryonic stem (ES) cells are undifferentiated pluripotent cells, meaning they can produce any cell type in the body. This gives them tremendous potential in science and medicine since they can generate specific cell types for use in research or to replace body cells lost due to damage or disease.
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Related Experiment Video

Updated: Dec 26, 2025

Isolation of Perivascular Multipotent Precursor Cell Populations from Human Cardiac Tissue
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Five Decades Later, Are Mesenchymal Stem Cells Still Relevant?

Mario Gomez-Salazar1, Zaniah N Gonzalez-Galofre1, Joan Casamitjana1

  • 1MRC Centre for Regenerative Medicine and Centre for Cardiovascular Science, The University of Edinburgh, Edinburgh, United Kingdom.

Frontiers in Bioengineering and Biotechnology
|March 19, 2020
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Summary

Mesenchymal stem cells (MSCs) are key for tissue repair, but their exact role was unclear. New research reveals their tissue origin and healing mechanisms through growth factors and immune interaction, advancing regenerative medicine.

Keywords:
adventitiacell therapymesenchymal stem cellpericytetissue engineering

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Last Updated: Dec 26, 2025

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Area of Science:

  • Regenerative Medicine
  • Stem Cell Biology
  • Tissue Engineering

Background:

  • Mesenchymal stem cells (MSCs) are mesodermal progenitors found in vascularized tissues.
  • The native identity and in vivo function of MSCs in tissue repair remain incompletely understood.
  • Current in vitro isolation methods for MSCs have remained largely unchanged for decades.

Purpose of the Study:

  • To review current trends in Mesenchymal stem cell biology.
  • To discuss how recent findings can improve MSC applications in tissue engineering and regenerative medicine.

Main Methods:

  • Review of recent scientific literature on Mesenchymal stem cell biology.
  • Analysis of MSC tissue origin, healing mechanisms, and therapeutic potential.

Main Results:

  • Recent investigations have elucidated the tissue origin of MSCs.
  • Alternative MSC functions, including growth factor secretion and immune modulation, are increasingly recognized.
  • Understanding these mechanisms offers new avenues for therapeutic applications.

Conclusions:

  • Advances in understanding MSC biology are crucial for improving their use in regenerative medicine.
  • Targeting MSCs' paracrine effects and immune interactions holds significant therapeutic promise.
  • Further research will enhance the efficacy of MSC-based therapies in tissue repair and engineering.