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The ASIA syndrome: basic concepts.

Abdulla Watad1,2, Kassem Sharif1,2, Yehuda Shoenfeld2

  • 1Department of Medicine 'B'.

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|March 19, 2020
PubMed
Summary
This summary is machine-generated.

Autoimmune/inflammatory syndrome induced by adjuvants (ASIA) involves autoimmune conditions triggered by adjuvant exposure. This review highlights growing evidence linking adjuvants to autoimmunity in genetically susceptible individuals.

Keywords:
ASIA syndromeadjuvantsautoantibodiesautoimmune/inflammatory syndrome induced by adjuvantsautoimmunitysiliconevaccine

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Area of Science:

  • Immunology
  • Autoimmunity
  • Vaccine Adjuvants

Background:

  • Autoimmune/inflammatory syndrome induced by adjuvants (ASIA), or Shoenfeld's syndrome, is a spectrum of autoimmune conditions.
  • Adjuvants are immune-boosting substances commonly used in vaccines.
  • ASIA presents with diverse clinical manifestations and severity.

Purpose of the Study:

  • To review current literature on ASIA syndrome.
  • To increase physician awareness of ASIA.
  • To highlight the link between adjuvants and autoimmunity.

Main Methods:

  • Literature review of studies on ASIA syndrome.
  • Analysis of data on adjuvant exposure and autoimmune responses.
  • Synthesis of clinical observations and research findings.

Main Results:

  • Adjuvants can trigger autoimmune phenomena in genetically predisposed individuals.
  • ASIA encompasses a heterogeneous range of autoimmune conditions.
  • Significant data link various adjuvants to the development or exacerbation of autoimmunity.

Conclusions:

  • ASIA is a recognized entity linked to adjuvant exposure.
  • Further research is needed to understand the mechanisms of ASIA.
  • Physician awareness and recognition of ASIA are crucial for patient management.