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Regulatory B cells in autoimmune rheumatic diseases
1Department of Rheumatology and Clinical Immunology, Faculty of Medicine, School of Health Sciences, University of Thessaly, Larissa, Greece.
Mediterranean Journal of Rheumatology
|March 19, 2020
Summary
Regulatory B cells (Breg cells) are crucial for immune regulation and preventing autoimmune diseases. Their deficiency in active rheumatic diseases highlights their potential as biomarkers and therapeutic targets.
Area of Science:
- Immunology
- Rheumatology
Background:
- Regulatory B cells (Breg cells) are increasingly recognized as key immunoregulatory factors.
- Breg cells play a critical role in maintaining immune homeostasis.
Purpose of the Study:
- To comprehensively review the involvement of Breg cells in various autoimmune rheumatic diseases.
- To explore the therapeutic potential of Breg cells in rheumatology.
Main Methods:
- A descriptive review of literature was conducted using PubMed.
- Keywords included "Bregs and rheumatoid arthritis", "systemic lupus erythematosus", and other rheumatic conditions.
- Relevant studies on Breg cells in autoimmune diseases were analyzed.
Main Results:
- Breg cells inhibit pro-inflammatory Th1 and Th17 cells, crucial for preventing autoimmune conditions.
- Breg cells exert regulatory effects via IL-10, IL-35, or TGFβ.
- Reduced Breg cell numbers are observed in active autoimmune diseases like rheumatoid arthritis and systemic sclerosis, with potential recovery during remission.
Conclusions:
- The diminished presence of IL-10+ Breg cells in active autoimmune rheumatic diseases suggests their utility as biomarkers.
- Breg cells represent a promising therapeutic target for managing autoimmune rheumatic diseases.
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