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Association between Takayasu arteritis and ischemic heart disease: a cohort study
Mathilde Versini1, Shmuel Tiosano2,3,4, Kassem Sharif2,3,4
1Department of Internal Medicine, Archet-1 Hospital, University of Nice-Sophia-Antipolis, Nice, France.
Mediterranean Journal of Rheumatology
|March 19, 2020
Summary
Takayasu arteritis (TA) patients have a higher risk of developing ischemic heart disease (IHD). This condition also significantly reduces long-term survival rates in individuals with TA.
Area of Science:
- Cardiology
- Rheumatology
- Vascular Medicine
Background:
- Takayasu arteritis (TA) is a rare, idiopathic large vessel vasculitis affecting the aorta and its branches.
- Understanding the association between TA and ischemic heart disease (IHD) is crucial for patient management and prognosis.
Purpose of the Study:
- To investigate the link between Takayasu arteritis (TA) and the incidence of ischemic heart disease (IHD).
- To assess the impact of TA and IHD on patient survival rates.
Main Methods:
- A comparative study using data from Clalit Health Services (CHS) in Israel.
- 155 TA patients were compared with 755 age- and gender-matched controls.
- Statistical analyses included chi-square tests, t-tests, logistic regression, Kaplan-Meier plots, and Cox regression.
Main Results:
- TA patients exhibited a significantly higher proportion of IHD (32.3%) compared to controls (8.9%, p<0.001).
- IHD was independently associated with TA (OR=6.576) and male gender (OR=2.29).
- Over 15 years, TA patients had higher all-causes mortality, with TA (HR=2.58) and IHD (HR=1.64) linked to reduced survival.
Conclusions:
- Takayasu arteritis is associated with an increased prevalence of ischemic heart disease.
- TA patients face a reduced 15-year survival rate compared to the general population.
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