Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Diseases of the Liver and Gallbladder01:26

Diseases of the Liver and Gallbladder

1.7K
Liver and gallbladder diseases are a significant health concern, with prominent conditions including cirrhosis, hepatitis, non-alcoholic fatty liver disease (NAFLD), and gallstones. Jaundice is a common manifestation of liver and biliary disease.
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not...
1.7K
Ultrasound II: Endoscopic Ultrasound and FibroScan01:25

Ultrasound II: Endoscopic Ultrasound and FibroScan

427
Endoscopic Ultrasound (EUS) and FibroScan are valuable diagnostic tools in gastroenterology and hepatology, each with specific applications and techniques.
Endoscopic Ultrasound (EUS):
427
Overview of Fatty Acid Metabolism01:28

Overview of Fatty Acid Metabolism

35.9K
Lipids also are sources of energy that power cellular processes. Like carbohydrates, lipids are composed of carbon, hydrogen, and oxygen, but these atoms are arranged differently. Most lipids are nonpolar and hydrophobic. Major types include fats and oils, waxes, phospholipids, and steroids.
Fatty acids are catabolized in a process called beta-oxidation, which takes place in the matrix of the mitochondria and converts their fatty acid chains into two-carbon units of acetyl groups. The acetyl...
35.9K
Chronic Pancreatitis I: Introduction01:24

Chronic Pancreatitis I: Introduction

613
The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
613
Liver Physiology01:30

Liver Physiology

3.4K
The liver, an essential organ in the human body, performs over 200 vital functions that can be broadly categorized into metabolic, hematological, endocrine regulation, and bile production.
Metabolic Regulation:
The liver is the central organ involved in regulating blood composition. It stabilizes blood glucose levels, maintaining them within the range of  70–110 mg/dL. When these levels drop, the liver breaks down glycogen reserves and releases glucose into the bloodstream. It can...
3.4K
Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test01:22

Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test

125
In clinical practice, the direct measurement of hepatic blood flow to evaluate liver function presents significant challenges due to the intricate and specialized nature of the necessary techniques. Consequently, healthcare professionals often rely on empirical estimates derived from thorough patient examinations and liver function tests to gauge liver health. Among the tools at their disposal, the Child–Pugh and MELD scoring systems stand out for their ability to categorize and assess...
125

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The Role of Hippocampal Microglial cGAS-STING Signaling Pathway in Postoperative Cognitive Dysfunction in Diabetic Mice.

Frontiers in bioscience (Landmark edition)·2026
Same author

Target-specific TMS-evoked motor-network responsiveness after acute ischaemic stroke.

Brain stimulation·2026
Same author

Hyperbaric Oxygen Treatment Attenuates Renal Ischemia/Reperfusion Injury in Rats.

Undersea & hyperbaric medicine : journal of the Undersea and Hyperbaric Medical Society, Inc·2026
Same author

Plasma metabolomics combined with machine learning for postoperative prognostic stratification in hormone receptor-positive/human epidermal growth factor receptor 2-negative early breast cancer.

Clinical nutrition ESPEN·2026
Same author

Individual heterogeneity in neuroimaging markers of functional outcomes in patients with acute ischaemic stroke.

Stroke and vascular neurology·2026
Same author

Synergistic effects of biochar and microbial inoculants on rice productivity and soil fertility are mediated by a nitrogen-dependent microbial pathway.

Frontiers in plant science·2026

Related Experiment Video

Updated: Dec 26, 2025

Novel In Vivo Micro-Computed Tomography Imaging Techniques for Assessing the Progression of Non-Alcoholic Fatty Liver Disease
08:41

Novel In Vivo Micro-Computed Tomography Imaging Techniques for Assessing the Progression of Non-Alcoholic Fatty Liver Disease

Published on: March 24, 2023

1.6K

Nonalcoholic Fatty Liver Disease.

Lingling Ding1, Yvonne Oligschlaeger1, Ronit Shiri-Sverdlov1

  • 1Department of Molecular Genetics, School of Nutrition and Translational Research in Metabolism (NUTRIM), Maastricht University Medical Center+, Maastricht, The Netherlands.

Handbook of Experimental Pharmacology
|March 19, 2020
PubMed
Summary

Nonalcoholic fatty liver disease (NAFLD), a key part of metabolic syndrome, shares many similarities with atherosclerosis. Research highlights increasing NAFLD prevalence, costs, and shared therapeutic strategies for both conditions.

Keywords:
AtherosclerosisEpidemiologyNAFLDPathogenesisTreatment

More Related Videos

Author Spotlight: Establishing MASLD Cell Models for Investigating Disease Mechanisms and the Lipid-Lowering Effects of Koumiss
07:03

Author Spotlight: Establishing MASLD Cell Models for Investigating Disease Mechanisms and the Lipid-Lowering Effects of Koumiss

Published on: July 19, 2024

1.5K
A Model of Experimental Steatosis In Vitro: Hepatocyte Cell Culture in Lipid Overload-Conditioned Medium
08:35

A Model of Experimental Steatosis In Vitro: Hepatocyte Cell Culture in Lipid Overload-Conditioned Medium

Published on: May 18, 2021

7.3K

Related Experiment Videos

Last Updated: Dec 26, 2025

Novel In Vivo Micro-Computed Tomography Imaging Techniques for Assessing the Progression of Non-Alcoholic Fatty Liver Disease
08:41

Novel In Vivo Micro-Computed Tomography Imaging Techniques for Assessing the Progression of Non-Alcoholic Fatty Liver Disease

Published on: March 24, 2023

1.6K
Author Spotlight: Establishing MASLD Cell Models for Investigating Disease Mechanisms and the Lipid-Lowering Effects of Koumiss
07:03

Author Spotlight: Establishing MASLD Cell Models for Investigating Disease Mechanisms and the Lipid-Lowering Effects of Koumiss

Published on: July 19, 2024

1.5K
A Model of Experimental Steatosis In Vitro: Hepatocyte Cell Culture in Lipid Overload-Conditioned Medium
08:35

A Model of Experimental Steatosis In Vitro: Hepatocyte Cell Culture in Lipid Overload-Conditioned Medium

Published on: May 18, 2021

7.3K

Area of Science:

  • Hepatology
  • Metabolic Diseases
  • Cardiovascular Medicine

Background:

  • Nonalcoholic fatty liver disease (NAFLD) is the liver manifestation of metabolic syndrome (MetS).
  • NAFLD represents a significant global health challenge in the 21st century.
  • There are striking similarities between NAFLD and atherosclerosis.

Purpose of the Study:

  • To review the current understanding of NAFLD.
  • To highlight the parallels between NAFLD and atherosclerosis.
  • To discuss the systemic implications and therapeutic strategies for NAFLD.

Main Methods:

  • Review of epidemiological data on NAFLD prevalence and costs.
  • Overview of the pathophysiology of NAFLD.
  • Analysis of systemic aspects and metabolic crosstalk in NAFLD.
  • Examination of therapeutic approaches for NAFLD and their comparison to atherosclerosis treatments.

Main Results:

  • NAFLD prevalence and associated costs are increasing significantly.
  • NAFLD involves complex pathophysiological hepatic processes.
  • Systemic aspects of NAFLD indicate crucial metabolic crosstalk between organs.
  • Investigated therapeutic approaches for NAFLD mirror those for atherosclerosis.

Conclusions:

  • NAFLD is a major health concern with increasing epidemiological impact.
  • The pathophysiology of NAFLD involves systemic metabolic interactions.
  • Therapeutic strategies for NAFLD show promise and overlap with atherosclerosis treatments.