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Molecular and Cellular Functions of CTLA-4

Samya Van Coillie1, Bartosz Wiernicki2, Jie Xu3

  • 1Molecular Signaling and Cell Death Unit, VIB-UGent Center for Inflammation Research, Zwijnaarde, 9052, Ghent, Belgium. samya.vancoillie@irc.vib-ugent.be.

Advances in Experimental Medicine and Biology
|March 19, 2020
PubMed
Summary

Cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) is a key immune checkpoint regulating T-cell responses. It primarily inhibits immune activation through cell-extrinsic mechanisms, impacting autoimmunity and cancer therapies.

Keywords:
CD28CD80CD86CTLA-4Immune tolerance

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