Risk assessment model for endpoints of ischemic stroke: A study protocol for a registry study

Area of Science:

• Neurology
• Integrative Medicine
• Epidemiology

Background:

• Ischemic stroke poses a significant health burden globally.
• Current risk assessment models primarily rely on conventional Western medicine indicators.
• There is a need to incorporate complementary approaches like Traditional Chinese Medicine (TCM) for comprehensive risk evaluation.

Purpose of the Study:

• To develop and validate a risk assessment model for ischemic stroke endpoints.
• To integrate Traditional Chinese Medicine (TCM) indicators with modern medicine data.
• To enhance the early detection, intervention, and management of ischemic stroke.

Main Methods:

• A registry-based survey involving 3000 ischemic stroke patients across seven Chinese hospitals.
• One-year follow-up including on-site and telephone monitoring for endpoint events.
• Statistical analyses including frequency analysis, X2 tests, rank-sum tests, and multivariate Cox proportional hazard models.

Main Results:

• Comparative analysis of endpoint event prevalence across different patient groups.
• Correlation analysis between endpoint events and integrated TCM and modern medicine factors.
• Development of a novel, combined risk assessment model.

Conclusions:

• The integrated risk assessment model incorporating both TCM and modern medicine indicators shows promise for improving ischemic stroke management.
• This novel approach has the potential to facilitate earlier warning, intervention, and control of stroke endpoints.
• Further validation and implementation of this model could significantly benefit patient outcomes.