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Trends in Nanomedicines for Cancer Treatment
Tatielle do Nascimento1, Adriane R Todeschini2, Ralph Santos-Oliveira3
1Laboratorio de Desenvolvimento Galenico, Farmacia Universitária, Centro de Ciencias da Saude, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
Background:
Cancer is characterized by abnormal cell growth and considered one of the leading causes of death around the world. Pharmaceutical Nanotechnology has been extensively studied for the optimization of cancer treatment.
Objective:
Comprehend the panorama of Pharmaceutical Nanotechnology in cancer treatment, through a survey about nanomedicines applied in clinical studies, approved for use and patented.
Methods:
Acknowledged products under clinical study and nanomedicines commercialized found in scientific articles through research on the following databases: Pubmed, Science Direct, Scielo and Lilacs. Derwent tool was used for patent research.
Results:
Nanomedicines based on nanoparticles, polymer micelles, liposomes, dendrimers and nanoemulsions were studied, along with cancer therapies such as Photodynamic Therapy, Infrared Phototherapy Hyperthermia, Magnetic Hyperthermia, Radiotherapy, Gene Therapy and Nanoimmunotherapy. Great advancement has been observed over nanotechnology applied to cancer treatment, mainly for nanoparticles and liposomes.
Conclusion:
The combination of drugs in nanosystems helps to increase efficacy and decrease toxicity. Based on the results encountered, nanoparticles and liposomes were the most commonly used nanocarriers for drug encapsulation. In addition, although few nanomedicines are commercially available, this specific research field is continuously growing.
Insights
Pharmaceutical nanotechnology offers optimized cancer treatment by enhancing drug efficacy and reducing toxicity. Nanoparticles and liposomes are leading nanocarriers in this rapidly advancing field.
Area of Science:
- Oncology
- Nanotechnology
- Pharmaceutical Sciences
Background:
- Cancer, marked by uncontrolled cell growth, remains a major global health challenge.
- Pharmaceutical nanotechnology is a key area of research for improving cancer therapies.
Purpose of the Study:
- To survey nanomedicines in clinical studies, approved applications, and patents for cancer treatment.
- To understand the current landscape of pharmaceutical nanotechnology in oncology.
Main Methods:
- Literature review of scientific articles from PubMed, Science Direct, Scielo, and Lilacs.
- Patent research utilizing the Derwent tool.
- Focus on nanomedicines including nanoparticles, liposomes, polymer micelles, dendrimers, and nanoemulsions.
Main Results:
- Nanomedicines studied encompass nanoparticles, liposomes, polymer micelles, dendrimers, and nanoemulsions.
- Therapeutic applications include Photodynamic Therapy, Hyperthermia (Infrared, Magnetic), Radiotherapy, Gene Therapy, and Nanoimmunotherapy.
- Significant progress is noted in nanotechnology for cancer treatment, particularly with nanoparticles and liposomes.
Conclusions:
- Nanosystems enhance drug efficacy and reduce toxicity in cancer treatment.
- Nanoparticles and liposomes are the most prevalent nanocarriers for drug delivery.
- Despite limited commercial availability, the field of nanomedicine for cancer is experiencing continuous growth.
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