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Genetic Screens02:46

Genetic Screens

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Genetic screens are tools used to identify genes and mutations responsible for phenotypes of interest. Genetic screens help identify individuals or a group of people at risk of developing  genetic diseases and help them with early intervention, targeted therapy, and reproductive options.
Forward genetic screens
Forward or “classical” genetic screens involve creating random mutations in an organism’s DNA using radiation, mutagens, or insertion of additional bases, which...
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Drug Discovery: Overview01:26

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Drug discovery is a multifaceted process involving extensive screening, testing, and optimization of lead compounds to identify potential new drugs for therapeutic use. It combines several approaches, including screening large numbers of natural products, chemical modification of known active molecules, identification of new drug targets, and rational design based on biological mechanisms and drug-receptor structure. These approaches are carried out in both academic research laboratories and...
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Related Experiment Video

Updated: Dec 26, 2025

A Fluorescence-based Lymphocyte Assay Suitable for High-throughput Screening of Small Molecules
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Creating and screening natural product libraries.

Brice A P Wilson1, Christopher C Thornburg, Curtis J Henrich

  • 1Molecular Targets Program, Center for Cancer Research, National Cancer Institute, Frederick, Maryland 21702-1201, USA. okeefeba@mail.nih.gov.

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|March 19, 2020
PubMed
Summary
This summary is machine-generated.

The National Cancer Institute (NCI) is creating a large library of natural product fractions for cancer research. This review details methods for library creation, screening, and identifying potential drug compounds.

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Area of Science:

  • Natural Product Chemistry
  • Drug Discovery
  • Cancer Research

Background:

  • The National Cancer Institute (NCI) initiated the Cancer Moonshot program, including the NCI Program for Natural Product Discovery.
  • A library of 1,000,000 partially purified natural product fractions is being generated and distributed to researchers.
  • The first 326,000 fractions are now available, supporting cancer drug discovery efforts.

Purpose of the Study:

  • To describe the methods for collecting organisms, extraction, and creating a prefractionated natural product library.
  • To detail cell-based and cell-free bioassay methods suitable for screening these natural product libraries.
  • To outline post-screen dereplication, compound purification, and scale-up procedures for preclinical development.

Main Methods:

  • Organism collection and extraction protocols.
  • Development of prefractionated natural product libraries in 384-well plates.
  • Adaptation of cell-based and cell-free bioassays for high-throughput screening.
  • Procedures for dereplication, purification, and scale-up of active natural products.

Main Results:

  • A comprehensive review of methodologies for natural product library generation and screening.
  • Detailed description of bioassay adaptations for efficient screening of natural product fractions.
  • Outline of strategies for identifying and producing potential anti-cancer compounds.

Conclusions:

  • The NCI Program for Natural Product Discovery provides a valuable resource for cancer research.
  • Standardized methods facilitate the creation and screening of large natural product libraries.
  • Efficient workflows enable the identification and development of novel natural product-based therapeutics.