[The action of Berberin-drops on the intraocular pressure (IOP) (author's transl)]

A double-blind trial was performed on 12 patients with chronic open angle glaucoma with Berberin and Placebo drops. There was no evidence for the hypothesis that Berberin or Placebo cause changes in the bio-regulation of the IOP. The statistical analysis was done by a new procedure (Kannemann 1976). The authors tried to propose generally valid rules for the planning of trials which are supposed to prove or disaprove the connection between various eye-drops and IOP-changes.