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Association Between Antipsychotics and Osteoporosis Based on Real-World Data
Satoshi Yokoyama1, Shoki Wakamoto1, Yuki Tanaka1
1Kindai University, Osaka, Japan.
The Annals of Pharmacotherapy
|March 19, 2020
Summary
This study found no link between antipsychotic use and osteoporosis onset in real-world data. Further research is needed to confirm these findings and assess causality.
Area of Science:
- Pharmacovigilance
- Epidemiology
- Public Health
Background:
- Osteoporosis is a significant public health issue impacting quality of life.
- Antipsychotics have been controversially linked to osteoporosis, possibly via elevated prolactin levels.
Purpose of the Study:
- To investigate the association between antipsychotic drug use and the risk of developing osteoporosis.
- To assess this relationship using real-world data from multiple sources.
Main Methods:
- A multimethod data-mining approach was employed.
- Disproportionality analysis of the US Food and Drug Administration Adverse Event Reporting System (FAERS) database (2004-2017).
- Sequence symmetry analysis of a Japanese administrative claims database (JMDC Inc, 2005-2017).
Main Results:
- No overall association between antipsychotic use and osteoporosis was found in the FAERS database, with exceptions for perphenazine.
- The Japanese claims database showed no association, except for sulpiride and aripiprazole.
- No single antipsychotic demonstrated significant signals across all analytical methods (ROR, IC, adjusted SR).
Conclusions:
- Real-world evidence suggests no association between antipsychotic use and osteoporosis onset.
- Further pharmacoepidemiological studies are required to definitively assess causality.
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