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Knowledge of Infectious Disease Specialists Regarding Aspergillosis Complicating Influenza, United States

Mitsuru Toda, Susan E Beekmann, Philip M Polgreen

    Emerging Infectious Diseases
    |March 19, 2020
    PubMed

    Insights

    Nearly one-fifth of US physicians encountered invasive pulmonary aspergillosis post-influenza. Routine use of galactomannan testing for this fungal infection remains low, despite its potential diagnostic value.

    Area of Science:

    • Medical Mycology
    • Infectious Diseases
    • Pulmonology

    Background:

    • Severe influenza infections can predispose patients to secondary fungal pneumonias.
    • Invasive pulmonary aspergillosis (IPA) is a serious opportunistic infection.
    • Early diagnosis of IPA is crucial for patient outcomes.

    Observation:

    • An online survey revealed that approximately 20% of responding US physicians had encountered IPA cases following severe influenza.
    • Physicians reported awareness of IPA in severe influenza cases at their institutions.

    Findings:

    • Despite the observed incidence of IPA post-influenza, less than 10% of physicians routinely employed galactomannan testing for diagnosis.
    • There is a significant gap between the recognition of IPA and its diagnostic workup in severe influenza patients.

    Implications:

    • This suggests underutilization of a key diagnostic biomarker for IPA in a vulnerable patient population.
    • Increased awareness and implementation of galactomannan testing could improve the diagnosis and management of IPA in severe influenza.
    • Further research is needed to understand barriers to galactomannan testing adoption.
    Keywords:
    United Statesfungigalactomannaninfectious disease specialistsinfluenzainfluenza virusinvasive pulmonary aspergillosisknowledgesevere influenzaviruses

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