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Updated: Dec 26, 2025

Murine Oropharyngeal Aspiration Model of Ventilator-associated and Hospital-acquired Bacterial Pneumonia
Published on: June 28, 2018
[MORAXELLA OSLOENSIS BACTEREMIA WITH PNEUMONIA: FIRST REPORTED CASE IN ISRAEL]
Valeriy Bilyk1, Othman Ali1, Ahmad Moghrabi1
1Galilee Medical Center, Department of Internal Medicine "D", Nahariya.
Introduction:
Community acquired pneumonia (CAP), an acute infection of the pulmonary parenchyma acquired in the community, is generally treated in an outpatient setting and involves different etiological agents. In the adult community, the most common pathogen in the disease is Streptococcus pneumonia, though other multiple etiological agents (atypical) have been involved, including Mycoplasma pneumoniae, Chlamydophila pneumoniae, and Legionella pneumophila. The genus Moraxella consists of aerobic, oxidase-positive gram-negative coccobacilli. Moraxella catarrhalis is known to be a common inhabitant of the upper respiratory tract and has been implicated as an etiologic agent in multiple diseases of the respiratory tract (but not limited to), such as bronchitis, pneumonia, otitis media, and sinusitis. The species Moraxella osloensis is a gram-negative opportunistic human pathogen, which has been found to cause several human diseases and infections such as meningitis, vaginitis, sinusitis, bacteremia, endocarditis, and septic arthritis. However, due to the subject's rarity, there is a paucity of information in the medical literature regarding its clinical significance, epidemiological data and appropriate therapy. We present the first case reported in Israel of Moraxella osloensis bacteremia in a patient with multiple co-morbidities including C. difficile infection (CDI) carrier state which presented with clinical symptoms (supported by radiological features) of community-acquired pneumonia. The patient was initially treated with empiric antibiotics including a 3rd generation cephalosporin and a macrolide that were substituted with IV Augmentin (Amoxicillin-Clavulanic acid) according to the organism's sensitivity tests. Our patient showed remarkable clinical and laboratory improvement with the therapy mentioned above.
Insights
This case study highlights Moraxella osloensis bacteremia presenting as community-acquired pneumonia (CAP) in a patient with co-morbidities. Effective treatment involved Amoxicillin-Clavulanic acid based on sensitivity testing.
Area of Science:
- Medical Microbiology
- Infectious Diseases
- Clinical Case Study
Background:
- Community-acquired pneumonia (CAP) is typically caused by Streptococcus pneumoniae and atypical pathogens.
- Moraxella species, including Moraxella catarrhalis and Moraxella osloensis, are gram-negative coccobacilli found in the respiratory tract.
- Moraxella osloensis is an opportunistic pathogen with limited reported clinical significance and data.
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