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Targeting Alpha Synuclein Aggregates in Cutaneous Peripheral Nerve Fibers by Free-floating Immunofluorescence Assay
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[SMALL FIBER POLYNEUROPATHY IN YOUNG PATIENTS]
Roi Treister1,2, Yardenor Mirski1,2, Liat Honigman1,2
1The Clinical Pain Innovation Laboratory, The Cheryl Spencer Department of Nursing, Faculty of Social Welfare.
Harefuah
|March 19, 2020
Summary
Small fiber polyneuropathy (SFPN) involves nerve damage affecting quality of life. Early diagnosis and removal of underlying causes are crucial for nerve recovery and improved patient outcomes.
Area of Science:
- Neurology
- Pathophysiology
Background:
- Small fiber polyneuropathy (SFPN) disrupts physiological balance, damaging small fiber neurons.
- Diabetes is the most common cause in Western countries; autoimmune conditions are prevalent in younger patients.
- SFPN presents with sensory and/or autonomic symptoms, significantly impacting quality of life.
Purpose of the Study:
- To highlight the importance of early and accurate diagnosis of SFPN.
- To emphasize the potential for nerve recovery upon identifying and removing etiological factors.
Main Methods:
- Diagnosis relies on skin biopsy and Autonomic-Functional-Testing.
- Recognizing diagnostic challenges when routine tests like EMG are normal.
Main Results:
- Delayed or missed diagnoses can occur, sometimes misattributed to non-organic causes.
- Prompt intervention is key, as peripheral nerve fibers can regenerate.
Conclusions:
- Early diagnosis of SFPN is essential for effective management.
- Identifying and addressing the underlying cause of SFPN can lead to significant patient recovery and improved quality of life.
