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Higher visit-to-visit blood pressure variability and N-terminal pro-brain natriuretic peptide elevation: influence of

Kosuke Takahari1, Michiaki Nagai2

  • 1Shobara City Soryo Clinic, Shobara.

Blood Pressure Monitoring
|March 19, 2020
PubMed

Insights

Visit-to-visit blood pressure variability (VVV) is linked to elevated N-terminal pro-brain natriuretic peptide (NT-proBNP) levels. This association persists even when considering left ventricular hypertrophy and diastolic dysfunction.

Area of Science:

  • Cardiology
  • Hypertension Research
  • Biomarker Analysis

Background:

  • Visit-to-visit blood pressure variability (VVV) is a debated factor in cardiovascular health.
  • The relationship between VVV and N-terminal pro-brain natriuretic peptide (NT-proBNP) requires clarification.
  • Potential mediating roles of left ventricular (LV) hypertrophy and diastolic dysfunction in this association are not fully understood.

Purpose of the Study:

  • To investigate the association between VVV and NT-proBNP levels in hypertensive patients.
  • To determine if LV hypertrophy and diastolic dysfunction mediate the relationship between VVV and NT-proBNP.

Main Methods:

  • Seventy-two hypertensive patients were monitored for 12 months.
  • Blood pressure variability was quantified using standard deviation, coefficient of variation (CV), and range (Δ).
  • Echocardiography assessed left ventricular mass index (LVMI) and mitral inflow velocity (E/e') to evaluate cardiac structure and function.

Main Results:

  • Significant correlations were found between NT-proBNP levels and measures of systolic and diastolic blood pressure variability (CV and Δ).
  • VVV measures did not show significant correlations with LVMI or E/e'.
  • Multiple regression analysis confirmed that higher CV and Δ of systolic blood pressure were independently associated with elevated NT-proBNP.

Conclusions:

  • Elevated visit-to-visit blood pressure variability is significantly associated with higher NT-proBNP levels.
  • This association is independent of left ventricular hypertrophy and diastolic dysfunction.
  • VVV may serve as an independent risk indicator in hypertensive individuals.
Abstract

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