Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

¹³C NMR: Distortionless Enhancement by Polarization Transfer (DEPT)01:20

¹³C NMR: Distortionless Enhancement by Polarization Transfer (DEPT)

1.5K
When proton-coupled carbon-13 spectra are simplified by a broadband proton decoupling technique, structural information about the coupled protons is lost. Distortionless enhancement by polarization transfer (DEPT) is a technique that provides information on the number of hydrogens attached to each carbon in a molecule. While the DEPT experiment utilizes complex pulse sequences, the pulse delay and flip angle are specifically manipulated. The resulting signals have different phases depending on...
1.5K
Computed Tomography01:10

Computed Tomography

7.9K
Tomography refers to imaging by sections. Computed tomography (CT) is a non-invasive imaging technique that uses computers to analyze several cross-sectional X-rays to reveal minute details about structures in the body.
The technique was invented in the 1970s and is based on the principle that as X-rays pass through the body, they are absorbed or reflected at different levels. In the technique, a patient lies on a motorized platform while a computerized axial tomography (CAT) scanner rotates...
7.9K
Electron Microscope Tomography and Single-particle Reconstruction01:07

Electron Microscope Tomography and Single-particle Reconstruction

2.7K
Transmission electron microscopy (TEM) can be used to determine the 3D structure of biological samples with the help of techniques such as electron microscope tomography and single-particle reconstruction. While single-particle reconstruction can examine macromolecules and macromolecular complexes in vitro conditions only, tomography permits the study of cell components or small cells in vivo.
Electron Tomography
Electron tomography can be performed either in TEM or STEM (scanning transmission...
2.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Lung ion-fluoroscopy Guided Hadron therapy: LIGHT concept and proof-of-principle.

Physics in medicine and biology·2026
Same author

Design, optimization, and validation of a novel applicator integrating real-time dose monitoring for ultra-high dose rate (FLASH) electron radiotherapy.

Physics in medicine and biology·2026
Same author

A novel deep-learning approach for monitoring gastrointestinal air variation during radiotherapy in young patients using radiographs.

Physics in medicine and biology·2026
Same author

Micro CT calibration accuracy for pre-clinical studies in ion therapy.

Physics in medicine and biology·2026
Same author

Simulation-Free Adaptive Prostate Stereotactic Body Radiation Therapy on Magnetic Resonance-Linac: Technical Feasibility and Clinical Experience.

International journal of radiation oncology, biology, physics·2026
Same author

Patient-specific fine-tuning of a self-distilled transformer model for normal tissue segmentation in abdominal magnetic resonance guided adaptive radiotherapy.

Physics and imaging in radiation oncology·2026

Related Experiment Video

Updated: Dec 26, 2025

Energy Dispersive X-ray Tomography for 3D Elemental Mapping of Individual Nanoparticles
10:00

Energy Dispersive X-ray Tomography for 3D Elemental Mapping of Individual Nanoparticles

Published on: July 5, 2016

12.2K

Parametrization of multi-energy CT projection data with eigentissue decomposition.

Mikaël Simard1,2, Arthur Lalonde1,3, Hugo Bouchard1,2,4

  • 1Département de physique, Université de Montréal, Complexe des sciences, 1375 Avenue Thérèse-Lavoie-Roux, Montréal, Québec H2V 0B3, Canada.

Physics in Medicine and Biology
|March 19, 2020
PubMed
Summary
This summary is machine-generated.

Eigentissue decomposition (ETD) optimizes human tissue characterization in multi-energy CT for improved radiotherapy accuracy. This method, based on principal component analysis, offers superior precision over conventional techniques for radiation therapy planning.

More Related Videos

Multi-modal Pulmonary Imaging: Using Complementary Information from CT and Hyperpolarized 129Xe MRI to Evaluate Lung Structure-Function
02:09

Multi-modal Pulmonary Imaging: Using Complementary Information from CT and Hyperpolarized 129Xe MRI to Evaluate Lung Structure-Function

Published on: April 12, 2024

932
Human Brown Adipose Tissue Depots Automatically Segmented by Positron Emission Tomography/Computed Tomography and Registered Magnetic Resonance Images
09:21

Human Brown Adipose Tissue Depots Automatically Segmented by Positron Emission Tomography/Computed Tomography and Registered Magnetic Resonance Images

Published on: February 18, 2015

12.5K

Related Experiment Videos

Last Updated: Dec 26, 2025

Energy Dispersive X-ray Tomography for 3D Elemental Mapping of Individual Nanoparticles
10:00

Energy Dispersive X-ray Tomography for 3D Elemental Mapping of Individual Nanoparticles

Published on: July 5, 2016

12.2K
Multi-modal Pulmonary Imaging: Using Complementary Information from CT and Hyperpolarized 129Xe MRI to Evaluate Lung Structure-Function
02:09

Multi-modal Pulmonary Imaging: Using Complementary Information from CT and Hyperpolarized 129Xe MRI to Evaluate Lung Structure-Function

Published on: April 12, 2024

932
Human Brown Adipose Tissue Depots Automatically Segmented by Positron Emission Tomography/Computed Tomography and Registered Magnetic Resonance Images
09:21

Human Brown Adipose Tissue Depots Automatically Segmented by Positron Emission Tomography/Computed Tomography and Registered Magnetic Resonance Images

Published on: February 18, 2015

12.5K

Area of Science:

  • Medical Physics
  • Radiotherapy Physics
  • Medical Imaging

Background:

  • Accurate human tissue characterization is crucial for precise radiotherapy planning.
  • Conventional multi-energy CT methods often rely on simplified or unphysical parameters for material description.

Purpose of the Study:

  • To propose an optimized parametrization of the attenuation coefficient for human tissues using eigentissue decomposition (ETD).
  • To evaluate the accuracy and precision of ETD for radiotherapy-related parameters compared to established methods.

Main Methods:

  • Eigentissue decomposition (ETD) using principal component analysis on reference human tissues.
  • Comparison of two ETD implementations against conventional pre-reconstruction formalisms in a multi-energy CT simulation framework.
  • Evaluation of reconstruction accuracy for radiotherapy quantities across 71 human tissues and various noise levels.

Main Results:

  • ETD significantly reduces mean error and root-mean-square error (RMSE) for proton stopping power and mass energy absorption coefficients.
  • The decomposition basis from principal component analysis proves superior to arbitrary material pairs for tissue description.
  • A classification-based ETD approach further enhances the reduction in errors for radiotherapy parameters.

Conclusions:

  • Parametrizing the attenuation coefficient with eigentissues offers a more accurate and precise method for evaluating human tissue properties in multi-energy CT for radiotherapy.
  • ETD enables accurate quantification without relying on unphysical parameters like the effective atomic number.
  • This approach enhances the reliability of radiotherapy planning and delivery.