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Thoracic, aortic arch and abdominal aneurysms are significant vascular conditions that can present with various clinical manifestations and lead to serious complications. Understanding these manifestations and the appropriate diagnostic studies is essential for effective management and treatment.Thoracic Aortic AneurysmsThoracic aortic aneurysms often remain asymptomatic until they reach a size that impinges on adjacent structures. They typically cause deep, diffuse chest pain that radiates to...
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Atherosclerosis is a progressive disorder that leads to the thickening and narrowing of arterial walls due to plaque buildup. This condition can cause various symptoms depending on the arteries affected:Coronary Artery Disease (CAD): This condition affects the coronary arteries and may lead to chest pain (angina), shortness of breath (dyspnea), heart attacks, and other heart disease symptoms.Cerebrovascular Disease: This affects blood flow to the brain, causing transient ischemic attacks (TIAs)...
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Updated: Dec 26, 2025

Precision Ultrasound-guided Stem Cell Delivery for Vascular Repair in Aortic Diseases
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Top 10 candidate aortic disease trials.

R L Dalman1, A Wanhainen2, K Mani2

  • 1From the, Division of Vascular Surgery, Department of Surgery, Stanford Medicine, Stanford, CA, USA.

Journal of Internal Medicine
|March 19, 2020
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Summary
This summary is machine-generated.

This review highlights critical research gaps in aortic disease, emphasizing the need for updated natural history data and novel therapies for abdominal aortic aneurysm (AAA). Further studies on biomarkers, genetics, and metformin

Keywords:
aneurysmaortaclinical trialsdissectionendovascularmedical treatmentsurgery

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Area of Science:

  • Cardiovascular Medicine
  • Vascular Surgery
  • Medical Research

Background:

  • Aortic diseases like aneurysm, dissection, and trauma are common and life-threatening.
  • Significant advancements have been made, yet substantial research opportunities remain.
  • Current treatments for abdominal aortic aneurysm (AAA) lack therapies for small aneurysms to prevent expansion and rupture.

Purpose of the Study:

  • To identify key areas for further study in aortic disease.
  • To prioritize essential aortic disease clinical trials.
  • To address limitations in current AAA management strategies.

Main Methods:

  • Literature review and analysis of current research trends.
  • Identification of knowledge gaps in aortic disease progression and treatment.
  • Selection of priority clinical trials for future investigation.

Main Results:

  • Need for updated AAA natural history data and endovascular repair roles.
  • Importance of defining biomarkers, genetic risk factors, and gender's influence.
  • Metformin identified as a potential drug candidate to slow AAA growth, requiring RCTs.

Conclusions:

  • Further research is crucial to refine understanding and treatment of aortic pathologies.
  • Clinical trials are warranted to validate metformin's efficacy in slowing AAA growth.
  • The role of endovascular treatment for ascending aortic pathologies and uncomplicated type B aortic dissection requires clarification.