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[Primary skull base chondrosarcoma: a clinicopathological analysis].
1Department of Pathology, the First Affiliated Hospital of Fujian Medical University, Fuzhou 350005, China.
Zhonghua Bing Li Xue Za Zhi = Chinese Journal of Pathology
|March 19, 2020
Summary
Primary skull base chondrosarcoma is a rare cartilaginous tumor. Characteristic morphology, immunohistochemistry, and molecular analysis aid in its diagnosis and indicate a good prognosis.
Area of Science:
- Oncology
- Pathology
- Molecular Biology
Background:
- Primary skull base chondrosarcoma is a rare malignant cartilaginous tumor.
- Understanding its clinicopathological and molecular features is crucial for accurate diagnosis.
Purpose of the Study:
- To investigate the clinicopathological features, immunophenotype, and molecular characteristics of primary skull base chondrosarcoma.
- To aid in the differential diagnosis of this rare tumor.
Main Methods:
- Retrospective review of nine primary skull base chondrosarcoma cases.
- Analysis of clinical, radiological, morphological, immunophenotypic (IHC), and molecular data.
Main Results:
- Nine cases (6 male, 3 female; median age 47) with WHO grade I (n=5) and II (n=4).
- Tumors showed lobulated growth, mild-moderate atypia, positive S-100, vimentin, SOX-9, D2-40, and negative Brachyury, CK, EMA, CK8/18.
- Low Ki-67 index (1-5%) and IDH1 R132C mutation in four cases.
Conclusions:
- Skull base chondrosarcoma is a rare malignant cartilaginous tumor with a favorable prognosis.
- Characteristic morphology, immunohistochemistry, and molecular detection are vital for differential diagnosis.
