Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Gene Therapy

Gene Therapy

Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be...

Microorganisms in Medicine and Therapeutics

Microorganisms in Medicine and Therapeutics

Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Intrinsic Disorder Status in Human Proteins Interacting With SARS-CoV-2 Proteins: Insights From Five Years of Translational Research.

Journal of cellular biochemistry·2026

Same author

Novel approach for vaccine delivery using mRNA lipid nanoparticles for <i>in vivo</i> production of monoclonal antibodies.

Molecular therapy. Nucleic acids·2026

Same author

Biomaterials in personalized drug delivery: innovations, challenges, and future directions.

PeerJ·2026

Same author

A Robust Bioprocess for the Global Incorporation of Noncanonical Amino Acids in Auxotrophic Hosts Produces Labeled Proteins at the Gram Scale.

Chembiochem : a European journal of chemical biology·2025

Same author

Looking at bacterial cell poles from a liquid-liquid phase separation of intrinsically disordered proteins perspective.

Current research in structural biology·2025

Same author

Effects of Molecular Crowding on the Structural, Dynamic, and Functional Properties of Biological Macromolecules: A General Overview.

Sub-cellular biochemistry·2025

Search research articles

Related Experiment Video

Updated: Dec 26, 2025

Paramyxoviruses for Tumor-targeted Immunomodulation: Design and Evaluation Ex Vivo

Paramyxoviruses for Tumor-targeted Immunomodulation: Design and Evaluation Ex Vivo

Published on: January 7, 2019

Viral Vector-Based Melanoma Gene Therapy.

Altijana Hromic-Jahjefendic¹, Kenneth Lundstrom²

¹Department of Genetics and Bioengineering, Faculty of Engineering and Natural Sciences, International University of Sarajevo, 71000 Sarajevo, Bosnia and Herzegovina.

|March 20, 2020

Summary

This summary is machine-generated.

Oncolytic virus gene therapy shows promise for cancer treatment, particularly for malignant melanoma. This review summarizes viral vector achievements in preclinical and clinical studies, highlighting untapped potential for melanoma.

Keywords:

cancer clinical trials gene therapy immunotherapy melanoma vector delivery

More Related Videos

Limbal Approach-Subretinal Injection of Viral Vectors for Gene Therapy in Mice Retinal Pigment Epithelium

Limbal Approach-Subretinal Injection of Viral Vectors for Gene Therapy in Mice Retinal Pigment Epithelium

Published on: August 7, 2015

Experimental Melanoma Immunotherapy Model Using Tumor Vaccination with a Hematopoietic Cytokine

Experimental Melanoma Immunotherapy Model Using Tumor Vaccination with a Hematopoietic Cytokine

Published on: February 24, 2023

Related Experiment Videos

Last Updated: Dec 26, 2025

Paramyxoviruses for Tumor-targeted Immunomodulation: Design and Evaluation Ex Vivo

Paramyxoviruses for Tumor-targeted Immunomodulation: Design and Evaluation Ex Vivo

Published on: January 7, 2019

Limbal Approach-Subretinal Injection of Viral Vectors for Gene Therapy in Mice Retinal Pigment Epithelium

Limbal Approach-Subretinal Injection of Viral Vectors for Gene Therapy in Mice Retinal Pigment Epithelium

Published on: August 7, 2015

Experimental Melanoma Immunotherapy Model Using Tumor Vaccination with a Hematopoietic Cytokine

Experimental Melanoma Immunotherapy Model Using Tumor Vaccination with a Hematopoietic Cytokine

Published on: February 24, 2023

Area of Science:

Oncology
Virology
Gene Therapy

Background:

Oncolytic viruses are explored as an alternative cancer treatment strategy.
Various viral vectors (adenoviruses, herpes simplex viruses, etc.) have been studied in preclinical and clinical settings for diverse cancers.
Current research emphasizes immunotherapy, with approved viral vector-based drugs, yet melanoma applications remain underdeveloped.

Purpose of the Study:

To review the achievements of preclinical and clinical studies utilizing viral vectors for cancer gene therapy.
To specifically focus on the application and potential of viral vectors in treating malignant melanoma.

Main Methods:

Literature review of preclinical and clinical studies on oncolytic viruses.
Analysis of viral vector applications across various cancer types.
Focused examination of studies pertaining to malignant melanoma.

Main Results:

Oncolytic viruses have demonstrated efficacy in treating various cancers like colon, head-and-neck, prostate, breast cancer, squamous cell carcinoma, and glioma.
Several viral vector-based drugs have gained approval, primarily for immunotherapy applications.
Malignant melanoma has not yet fully benefited from gene therapy approaches using viral vectors.

Conclusions:

Oncolytic virus gene therapy holds significant potential for cancer treatment.
Further research and development are needed to fully exploit viral vector applications for malignant melanoma.
This review highlights the progress and future directions for oncolytic virotherapy in melanoma.