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Acute Kidney Injury Model Induced by Cisplatin in Adult Zebrafish

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Published on: May 15, 2021

Physiological responses to cisplatin using a mouse hypersensitivity model.

David M Lehmann¹, Wanda C Williams¹

¹Center for Public Health & Environmental Assessment (CPHEA), US - Environmental Protection Agency, Durham, NC, USA.

Inhalation Toxicology

|March 20, 2020

Summary

This summary is machine-generated.

Dermal exposure to cisplatin (CDDP) can induce type I hypersensitivity, leading to respiratory issues. A single respiratory challenge is sufficient to elicit pulmonary responses in sensitized mice.

Keywords:

Platinum cisplatin occupational asthma pulmonary hyperresponsiveness respiratory hypersensitivity whole-body plethysmography

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Contact Hypersensitivity as a Murine Model of Allergic Contact Dermatitis

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Area of Science:

Immunology
Pulmonology
Toxicology

Background:

The mechanisms of respiratory hypersensitivity to cisplatin (CDDP) are not fully understood.
Type I hypersensitivity is suspected, but CDDP's potential to induce it requires direct evaluation in animal models.

Purpose of the Study:

To investigate the development of CDDP-induced respiratory hypersensitivity.
To evaluate CDDP's potential to induce type I hypersensitivity responses in a mouse model.

Main Methods:

Mice were topically sensitized with CDDP, followed by oropharyngeal aspiration (OPA) challenge.
Pulmonary responses were assessed using whole body plethysmography (WBP) and bronchoalveolar lavage fluid (BALF) analysis.

Main Results:

CDDP sensitization led to elevated Penh values and reduced respiratory rate upon methacholine challenge.
BALF analysis revealed increased eosinophils in CDDP-sensitized mice, indicating type I hypersensitivity.
Neutrophil counts increased in BALF regardless of sensitization status after CDDP challenge.

Conclusions:

Dermal CDDP exposure induces immunological changes consistent with type I hypersensitivity.
A single respiratory challenge can trigger pulmonary responses in dermally sensitized mice.
This study provides novel insights into CDDP hypersensitivity mechanisms.