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Inflammatory Markers in Cardiovascular Disease; Lessons Learned and Future Perspectives
Dimitrios Patoulias1, Konstantinos Stavropoulos1, Konstantinos Imprialos1
1Second Propedeutic Department of Internal Medicine, Aristotle University, Thessaloniki, Greece.
Current Vascular Pharmacology
|March 20, 2020
Summary
Inflammation is key in cardiovascular disease (CVD). This review explores inflammatory markers, like C-reactive protein, for CVD diagnosis and prevention, highlighting their potential as therapeutic targets.
Area of Science:
- Cardiovascular Medicine
- Inflammation Research
- Biomarker Discovery
Background:
- Cardiovascular disease (CVD) is a leading global cause of death.
- Inflammation is recognized as a critical factor in atherosclerosis and atherothrombosis.
- Understanding inflammatory markers is vital for CVD management.
Purpose of the Study:
- To review and critically evaluate evidence on inflammatory markers for CVD.
- To assess the utility of established and novel inflammatory markers in CVD.
- To explore the therapeutic potential of targeting inflammation in CVD.
Main Methods:
- Comprehensive literature search of MEDLINE up to November 2018.
- Inclusion of meta-analyses, randomized controlled trials, and observational studies.
- Evaluation of studies on general populations and patients with established CVD.
Main Results:
- Established markers like C-reactive protein show efficacy in CVD prevention.
- Novel markers (e.g., Lp-PLA2, cytokines, MPO) are under investigation.
- Some markers show promise as biomarkers and therapeutic targets for CVD.
Conclusions:
- Significant evidence supports inflammatory markers in CVD diagnosis and prognosis.
- Further research needed on multimarker models, cut-off values, and cost-effectiveness.
- Integration into clinical practice requires further validation.
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