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Updated: Dec 26, 2025
Halogenated Agent Delivery in Porcine Model of Acute Respiratory Distress Syndrome via an Intensive Care Unit Type Device
Published on: September 24, 2020
[Coronavirus disease 2019 (COVID-19): update for anesthesiologists and intensivists March 2020]
D Thomas-Rüddel1,2, J Winning1, P Dickmann1,2
1Klinik für Anästhesiologie und Intensivmedizin, Universitätsklinikum Jena, Am Klinikum 1, 07747, Jena, Deutschland.
Insights
The COVID-19 outbreak in Germany presents with mild to severe cases requiring intensive care. Severe cases show a prolonged lung function decline, unlike sepsis, and require specific management strategies.
Area of Science:
- Infectious Diseases
- Critical Care Medicine
- Public Health
Background:
- The novel coronavirus disease (COVID-19) outbreak has impacted Germany.
- While most infections are mild, severe cases necessitate intensive care.
- Severe COVID-19 courses exhibit a distinct prolonged progression of lung function deterioration.
Purpose of the Study:
- To outline the characteristics of severe COVID-19 cases in Germany.
- To highlight diagnostic approaches for COVID-19.
- To emphasize critical care management and infection prevention strategies.
Main Methods:
- Diagnosis is confirmed via Polymerase Chain Reaction (PCR) on respiratory specimens.
- Clinical observation of disease progression and severity.
- Review of intensive care unit (ICU) management protocols.
Main Results:
- Severe Acute Respiratory Distress Syndrome (ARDS) is a key indicator of critical COVID-19 illness.
- Prolonged respiratory compromise is characteristic of severe disease.
- Intensive care departments face significant challenges in managing these patients.
Conclusions:
- Effective prevention of nosocomial infections, including proper personal protective equipment (PPE) use, is crucial.
- Maintaining hospital operational capacity is vital during the pandemic.
- Anesthesia, intensive care, and emergency medicine departments must prepare for substantial challenges posed by COVID-19.
Abstract:
The current outbreak of coronavirus disease (COVID-19) has reached Germany. The majority of people infected present with mild disease, but there are severe cases that need intensive care. Unlike other acute infectious diseases progressing to sepsis, the severe courses of COVID19 seemingly show prolonged progression from onset of first symptoms to life-threatening deterioration of (primarily) lung function. Diagnosis relies on PCR using specimens from the respiratory tract. Severe ARDS reflects the hallmark of a critical course of the disease. Preventing nosocomial infections (primarily by correct use of personal protective equipment) and maintenance of hospitals' operational capability are of utmost importance. Departments of Anaesthesia, Intensive Care and emergency medicine will envisage major challenges.
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